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Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management

PURPOSE OF REVIEW: Intracranial germinomas constitute a rare brain tumor entity of unknown etiology, characterized by unique histopathology and molecular biology. In this manuscript, we review the literature focusing on the epidemiology, histopathology with molecular biology, clinical presentation w...

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Autores principales: Kremenevski, Natalia, Buchfelder, Michael, Hore, Nirjhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256636/
https://www.ncbi.nlm.nih.gov/pubmed/37036624
http://dx.doi.org/10.1007/s11912-023-01416-2
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author Kremenevski, Natalia
Buchfelder, Michael
Hore, Nirjhar
author_facet Kremenevski, Natalia
Buchfelder, Michael
Hore, Nirjhar
author_sort Kremenevski, Natalia
collection PubMed
description PURPOSE OF REVIEW: Intracranial germinomas constitute a rare brain tumor entity of unknown etiology, characterized by unique histopathology and molecular biology. In this manuscript, we review the literature focusing on the epidemiology, histopathology with molecular biology, clinical presentation with emphasis on tumor location, diagnostic workup, and current treatment strategies with related clinical outcomes of intracranial germinomas. RECENT FINDINGS: Although the optimal treatment strategy remains a matter of debate, intracranial germinomas respond well to radiotherapy, chemotherapy, or a combination of both and are characterized by very high cure and survival rates. It is well-known that early discrimination of germinomas from other intracranial neoplasms facilitates the timely initiation of appropriate treatment, thereby contributing to the reduction of morbidity as well as mortality. SUMMARY: Ongoing research will need to be directed towards discovering and refining reliable parameters for early diagnosis and evaluation of prognosis in patients with intracranial germinomas.
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spelling pubmed-102566362023-06-11 Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management Kremenevski, Natalia Buchfelder, Michael Hore, Nirjhar Curr Oncol Rep Article PURPOSE OF REVIEW: Intracranial germinomas constitute a rare brain tumor entity of unknown etiology, characterized by unique histopathology and molecular biology. In this manuscript, we review the literature focusing on the epidemiology, histopathology with molecular biology, clinical presentation with emphasis on tumor location, diagnostic workup, and current treatment strategies with related clinical outcomes of intracranial germinomas. RECENT FINDINGS: Although the optimal treatment strategy remains a matter of debate, intracranial germinomas respond well to radiotherapy, chemotherapy, or a combination of both and are characterized by very high cure and survival rates. It is well-known that early discrimination of germinomas from other intracranial neoplasms facilitates the timely initiation of appropriate treatment, thereby contributing to the reduction of morbidity as well as mortality. SUMMARY: Ongoing research will need to be directed towards discovering and refining reliable parameters for early diagnosis and evaluation of prognosis in patients with intracranial germinomas. Springer US 2023-04-10 2023 /pmc/articles/PMC10256636/ /pubmed/37036624 http://dx.doi.org/10.1007/s11912-023-01416-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kremenevski, Natalia
Buchfelder, Michael
Hore, Nirjhar
Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
title Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
title_full Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
title_fullStr Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
title_full_unstemmed Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
title_short Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
title_sort intracranial germinomas: diagnosis, pathogenesis, clinical presentation, and management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256636/
https://www.ncbi.nlm.nih.gov/pubmed/37036624
http://dx.doi.org/10.1007/s11912-023-01416-2
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