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The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age
The interplay between biomarkers of relevance to neuroplasticity and its association with learning and cognitive ability in old age remains poorly understood. The present study investigated acute changes in plasma concentrations of mature brain-derived neurotrophic factor (mBDNF), its precursor prot...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256682/ https://www.ncbi.nlm.nih.gov/pubmed/37296176 http://dx.doi.org/10.1038/s41598-023-35847-5 |
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author | Nilsson, Jonna Ekblom, Maria Moberg, Marcus Lövdén, Martin |
author_facet | Nilsson, Jonna Ekblom, Maria Moberg, Marcus Lövdén, Martin |
author_sort | Nilsson, Jonna |
collection | PubMed |
description | The interplay between biomarkers of relevance to neuroplasticity and its association with learning and cognitive ability in old age remains poorly understood. The present study investigated acute changes in plasma concentrations of mature brain-derived neurotrophic factor (mBDNF), its precursor protein (pro-BDNF), and cortisol, in response to acute physical exercise and cognitive training interventions, their covariation and role in predicting cognitive performance. Confirmatory results provided no support for mBDNF, pro-BDNF and cortisol co-varying over time, as the acute interventions unfolded, but did confirm a positive association between mBDNF and pro-BDNF at rest. The confirmatory results did not support the hypothesis that mBDNF change following physical exercise were counteracted by temporally coupled changes in cortisol or pro-BDNF, or by cortisol at rest, in its previously demonstrated faciliatory effect on cognitive training outcome. Exploratory results instead provided indications of a general and trait-like cognitive benefit of exhibiting greater mBDNF responsiveness to acute interventions when coupled with lesser cortisol responsiveness, greater pro-BDNF responsiveness, and lower cortisol at rest. As such, the results call for future work to test whether certain biomarker profiles are associated with preserved cognition in old age. |
format | Online Article Text |
id | pubmed-10256682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102566822023-06-11 The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age Nilsson, Jonna Ekblom, Maria Moberg, Marcus Lövdén, Martin Sci Rep Article The interplay between biomarkers of relevance to neuroplasticity and its association with learning and cognitive ability in old age remains poorly understood. The present study investigated acute changes in plasma concentrations of mature brain-derived neurotrophic factor (mBDNF), its precursor protein (pro-BDNF), and cortisol, in response to acute physical exercise and cognitive training interventions, their covariation and role in predicting cognitive performance. Confirmatory results provided no support for mBDNF, pro-BDNF and cortisol co-varying over time, as the acute interventions unfolded, but did confirm a positive association between mBDNF and pro-BDNF at rest. The confirmatory results did not support the hypothesis that mBDNF change following physical exercise were counteracted by temporally coupled changes in cortisol or pro-BDNF, or by cortisol at rest, in its previously demonstrated faciliatory effect on cognitive training outcome. Exploratory results instead provided indications of a general and trait-like cognitive benefit of exhibiting greater mBDNF responsiveness to acute interventions when coupled with lesser cortisol responsiveness, greater pro-BDNF responsiveness, and lower cortisol at rest. As such, the results call for future work to test whether certain biomarker profiles are associated with preserved cognition in old age. Nature Publishing Group UK 2023-06-09 /pmc/articles/PMC10256682/ /pubmed/37296176 http://dx.doi.org/10.1038/s41598-023-35847-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nilsson, Jonna Ekblom, Maria Moberg, Marcus Lövdén, Martin The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age |
title | The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age |
title_full | The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age |
title_fullStr | The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age |
title_full_unstemmed | The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age |
title_short | The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age |
title_sort | role of acute changes in mbdnf, cortisol and pro-bdnf in predicting cognitive performance in old age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256682/ https://www.ncbi.nlm.nih.gov/pubmed/37296176 http://dx.doi.org/10.1038/s41598-023-35847-5 |
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