Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile

Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the treatment of cancer. However, attenuation of virulence, which is generally required for the development of OVs based on pathogenic viral backbones, is frequently accompanied by a compromised killing effect on tumo...

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Detalles Bibliográficos
Autores principales: Guo, Li, Hu, Cheng, Liu, Yang, Chen, Xiaoyu, Song, Deli, Shen, Runling, Liu, Zhanzhen, Jia, Xudong, Zhang, Qinfen, Gao, Yuanzhu, Deng, Zhezhi, Zuo, Tao, Hu, Jun, Zhu, Wenbo, Cai, Jing, Yan, Guangmei, Liang, Jiankai, Lin, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256765/
https://www.ncbi.nlm.nih.gov/pubmed/37296165
http://dx.doi.org/10.1038/s41467-023-39156-3

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