Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific inhibitor of ClC-2. However, experimental structures are stil...

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Detalles Bibliográficos
Autores principales: Ma, Tao, Wang, Lei, Chai, Anping, Liu, Chao, Cui, Wenqiang, Yuan, Shuguang, Wing Ngor Au, Shannon, Sun, Liang, Zhang, Xiaokang, Zhang, Zhenzhen, Lu, Jianping, Gao, Yuanzhu, Wang, Peiyi, Li, Zhifang, Liang, Yujie, Vogel, Horst, Wang, Yu Tian, Wang, Daping, Yan, Kaige, Zhang, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256776/
https://www.ncbi.nlm.nih.gov/pubmed/37296152
http://dx.doi.org/10.1038/s41467-023-39218-6

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