Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic

Antibiotics that have multiple cellular targets theoretically reduce the frequency of resistance evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are understudied. Here we investigate these in methicillin resistant Staphylococcus aureus (MRSA) using experimenta...

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Detalles Bibliográficos
Autores principales: Silva, Kalinga Pavan T., Sundar, Ganesh, Khare, Anupama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256781/
https://www.ncbi.nlm.nih.gov/pubmed/37296157
http://dx.doi.org/10.1038/s41467-023-38507-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256781/
https://www.ncbi.nlm.nih.gov/pubmed/37296157
http://dx.doi.org/10.1038/s41467-023-38507-4

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