Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the “omnigenic” sparse effector hypothesis of complex trait genetics

The “omnigenic” hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated through trans-effects on expression of a relatively sparse set of effector (“core”) genes. We tested this hypothesis in a study of 4,964 cases of type 1 diabetes (T1D) and 7,497 co...

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Detalles Bibliográficos
Autores principales: Iakovliev, Andrii, McGurnaghan, Stuart J., Hayward, Caroline, Colombo, Marco, Lipschutz, Debby, Spiliopoulou, Athina, Colhoun, Helen M., McKeigue, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257008/
https://www.ncbi.nlm.nih.gov/pubmed/37164005
http://dx.doi.org/10.1016/j.ajhg.2023.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257008/
https://www.ncbi.nlm.nih.gov/pubmed/37164005
http://dx.doi.org/10.1016/j.ajhg.2023.04.003

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