BLIMP1 and NR4A3 Transcription Factors Reciprocally Regulate Antitumor CAR T-cell Stemness and Exhaustion

Chimeric antigen receptor (CAR) T cells have not induced meaningful clinical responses in solid tumors. Loss of T cell stemness, poor expansion capacity, and exhaustion during prolonged tumor antigen exposure are major causes of CAR T cell therapeutic resistance. Single-cell RNA-sequencing analysis...

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Detalles Bibliográficos
Autores principales: Jung, In-Young, Narayan, Vivek, McDonald, Sierra, Rech, Andrew J., Bartoszek, Robert, Hong, Gwanui, Davis, Megan M., Xu, Jun, Boesteanu, Alina C., Barber-Rotenberg, Julie S., Plesa, Gabriela, Lacey, Simon F., Jadlowsky, Julie K., Siegel, Donald L., Hammill, Dana M., Cho-Park, Park F., Berger, Shelley L., Haas, Naomi B., Fraietta, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257143/
https://www.ncbi.nlm.nih.gov/pubmed/36350986
http://dx.doi.org/10.1126/scitranslmed.abn7336

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