A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance

Temozolomide (TMZ) is an anticancer agent used to treat glioblastoma, typically following radiation therapy and/or surgical resection. However, despite its effectiveness, at least 50% of patients do not respond to TMZ, which is associated with repair and/or tolerance of TMZ-induced DNA lesions. Stud...

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Detalles Bibliográficos
Autores principales: Song, Ying-Qi, Li, Guo-Dong, Niu, Dou, Chen, Feng, Jing, Shaozhen, Wai Wong, Vincent Kam, Wang, Wanhe, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257196/
https://www.ncbi.nlm.nih.gov/pubmed/37305785
http://dx.doi.org/10.1016/j.jpha.2023.04.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257196/
https://www.ncbi.nlm.nih.gov/pubmed/37305785
http://dx.doi.org/10.1016/j.jpha.2023.04.010

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