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The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old

BACKGROUND: Stroke has been found to be highly correlated with the triglyceride-glucose (TyG) index. The relation between the TyG index changes and stroke, however, has seldom been reported, and current researches mentioning the TyG index concentrate on individual values. We aimed to investigate whe...

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Autores principales: Wu, Yaoling, Yang, Yongbiao, Zhang, Jinsheng, Liu, Shuo, Zhuang, Weiduan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257314/
https://www.ncbi.nlm.nih.gov/pubmed/37296457
http://dx.doi.org/10.1186/s12933-023-01870-z
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author Wu, Yaoling
Yang, Yongbiao
Zhang, Jinsheng
Liu, Shuo
Zhuang, Weiduan
author_facet Wu, Yaoling
Yang, Yongbiao
Zhang, Jinsheng
Liu, Shuo
Zhuang, Weiduan
author_sort Wu, Yaoling
collection PubMed
description BACKGROUND: Stroke has been found to be highly correlated with the triglyceride-glucose (TyG) index. The relation between the TyG index changes and stroke, however, has seldom been reported, and current researches mentioning the TyG index concentrate on individual values. We aimed to investigate whether the level and the change of TyG index was associated with the incidence of stroke. METHODS: Sociodemographic, medical background, anthropometric and laboratory information were retrospectively collected. Classification was conducted using k-means clustering analysis. Logistic regressions were to determine the relationship between different classes with changes in the TyG index and incidence of stroke, taking the class with the smallest change as a reference. Meanwhile, restricted cubic spline regression was applied to examine the links of cumulative TyG index and stroke. RESULTS: 369 (7.8%) of 4710 participants had a stroke during 3 years. Compared to class 1 with the best control of the TyG Index, the OR for class 2 with good control was 1.427 (95% CI, 1.051–1.938), the OR for class 3 with moderate control was 1.714 (95% CI, 1.245–2.359), the OR for class 4 with worse control was 1.814 (95% CI, 1.257–2.617), and the OR for class 5 with consistently high levels was 2.161 (95% CI, 1.446–3.228). However, after adjusting for multiple factors, only class 3 still had an association with stroke (OR 1.430, 95%CI, 1.022-2.000). The relation between the cumulative TyG index and stroke was linear in restricted cubic spline regression. In subgroup analysis, similar results were shown in participants without diabetes or dyslipidemia. There is neither additive nor multiplicative interaction between TyG index class and covariates. CONCLUSION: A constant higher level with worst control in TyG index indicated a higher risk of stroke.
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spelling pubmed-102573142023-06-11 The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old Wu, Yaoling Yang, Yongbiao Zhang, Jinsheng Liu, Shuo Zhuang, Weiduan Cardiovasc Diabetol Research BACKGROUND: Stroke has been found to be highly correlated with the triglyceride-glucose (TyG) index. The relation between the TyG index changes and stroke, however, has seldom been reported, and current researches mentioning the TyG index concentrate on individual values. We aimed to investigate whether the level and the change of TyG index was associated with the incidence of stroke. METHODS: Sociodemographic, medical background, anthropometric and laboratory information were retrospectively collected. Classification was conducted using k-means clustering analysis. Logistic regressions were to determine the relationship between different classes with changes in the TyG index and incidence of stroke, taking the class with the smallest change as a reference. Meanwhile, restricted cubic spline regression was applied to examine the links of cumulative TyG index and stroke. RESULTS: 369 (7.8%) of 4710 participants had a stroke during 3 years. Compared to class 1 with the best control of the TyG Index, the OR for class 2 with good control was 1.427 (95% CI, 1.051–1.938), the OR for class 3 with moderate control was 1.714 (95% CI, 1.245–2.359), the OR for class 4 with worse control was 1.814 (95% CI, 1.257–2.617), and the OR for class 5 with consistently high levels was 2.161 (95% CI, 1.446–3.228). However, after adjusting for multiple factors, only class 3 still had an association with stroke (OR 1.430, 95%CI, 1.022-2.000). The relation between the cumulative TyG index and stroke was linear in restricted cubic spline regression. In subgroup analysis, similar results were shown in participants without diabetes or dyslipidemia. There is neither additive nor multiplicative interaction between TyG index class and covariates. CONCLUSION: A constant higher level with worst control in TyG index indicated a higher risk of stroke. BioMed Central 2023-06-09 /pmc/articles/PMC10257314/ /pubmed/37296457 http://dx.doi.org/10.1186/s12933-023-01870-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wu, Yaoling
Yang, Yongbiao
Zhang, Jinsheng
Liu, Shuo
Zhuang, Weiduan
The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
title The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
title_full The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
title_fullStr The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
title_full_unstemmed The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
title_short The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
title_sort change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257314/
https://www.ncbi.nlm.nih.gov/pubmed/37296457
http://dx.doi.org/10.1186/s12933-023-01870-z
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