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Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs

BACKGROUND: Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations may be affected by the hydration status. AIM: This study aimed to evaluate the effect of dehydration on plasma NT-proANP and NT-proBNP concentratio...

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Autores principales: Ogawa, Mizuki, Kojima, Yuki, Ishizaka, Mio, Miyakawa, Hirosumi, Hsu, Huai-hsun, Miyagawa, Yuichi, Takemura, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of Veterinary Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257462/
https://www.ncbi.nlm.nih.gov/pubmed/37304609
http://dx.doi.org/10.5455/OVJ.2023.v13.i5.13
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author Ogawa, Mizuki
Kojima, Yuki
Ishizaka, Mio
Miyakawa, Hirosumi
Hsu, Huai-hsun
Miyagawa, Yuichi
Takemura, Naoyuki
author_facet Ogawa, Mizuki
Kojima, Yuki
Ishizaka, Mio
Miyakawa, Hirosumi
Hsu, Huai-hsun
Miyagawa, Yuichi
Takemura, Naoyuki
author_sort Ogawa, Mizuki
collection PubMed
description BACKGROUND: Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations may be affected by the hydration status. AIM: This study aimed to evaluate the effect of dehydration on plasma NT-proANP and NT-proBNP concentrations in healthy dogs. METHODS: This prospective study included five clinically healthy dogs. Furosemide was administered intravenously at 2–4 mg/kg every 1–2 hours until completion of the dehydration model. The dehydration model was considered complete when weight loss was ≥5% and findings of dehydration on physical examination were observed. Plasma NT-proANP and NT-proBNP concentrations were compared at three-time points: before the dehydration model was created (point 1), at the completion of the dehydration model (point 2), and when dehydration was judged to have improved (point 3). Association between plasma NT-proANP and NT-proBNP concentrations, and each clinical variable (physical examination, blood pressure, blood chemistry, blood gases, and echocardiography) was assessed using linear regression analysis. RESULTS: Plasma NT-proANP concentration decreased significantly from point 2 to point 1 (p < 0.05), whereas plasma NT-proBNP concentration showed a decreasing trend but did not differ significantly between points 1 and 2. Plasma NT-proANP concentration correlated significantly with body weight (R(2) = 0.178) and plasma NT-proBNP concentration (R(2) = 0.284) (p < 0.05, respectively), and plasma NT-proBNP concentration correlated significantly with electrolytes (sodium, R(2) = 0.439; potassium, R(2) = 0.444; and chloride, R(2) = 0.419), and echocardiographic parameters [diastolic left ventricular internal diameter (LVIDd) R(2) = 0.519; weight-standardized LVIDd, R(2) = 0.535] (p < 0.01, respectively). CONCLUSION: The plasma NT-proANP concentrations decreased with dehydration. However, the plasma NT-proBNP concentration did not change with mild dehydration and reflected left ventricular morphology.
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spelling pubmed-102574622023-06-11 Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs Ogawa, Mizuki Kojima, Yuki Ishizaka, Mio Miyakawa, Hirosumi Hsu, Huai-hsun Miyagawa, Yuichi Takemura, Naoyuki Open Vet J Original Research BACKGROUND: Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations may be affected by the hydration status. AIM: This study aimed to evaluate the effect of dehydration on plasma NT-proANP and NT-proBNP concentrations in healthy dogs. METHODS: This prospective study included five clinically healthy dogs. Furosemide was administered intravenously at 2–4 mg/kg every 1–2 hours until completion of the dehydration model. The dehydration model was considered complete when weight loss was ≥5% and findings of dehydration on physical examination were observed. Plasma NT-proANP and NT-proBNP concentrations were compared at three-time points: before the dehydration model was created (point 1), at the completion of the dehydration model (point 2), and when dehydration was judged to have improved (point 3). Association between plasma NT-proANP and NT-proBNP concentrations, and each clinical variable (physical examination, blood pressure, blood chemistry, blood gases, and echocardiography) was assessed using linear regression analysis. RESULTS: Plasma NT-proANP concentration decreased significantly from point 2 to point 1 (p < 0.05), whereas plasma NT-proBNP concentration showed a decreasing trend but did not differ significantly between points 1 and 2. Plasma NT-proANP concentration correlated significantly with body weight (R(2) = 0.178) and plasma NT-proBNP concentration (R(2) = 0.284) (p < 0.05, respectively), and plasma NT-proBNP concentration correlated significantly with electrolytes (sodium, R(2) = 0.439; potassium, R(2) = 0.444; and chloride, R(2) = 0.419), and echocardiographic parameters [diastolic left ventricular internal diameter (LVIDd) R(2) = 0.519; weight-standardized LVIDd, R(2) = 0.535] (p < 0.01, respectively). CONCLUSION: The plasma NT-proANP concentrations decreased with dehydration. However, the plasma NT-proBNP concentration did not change with mild dehydration and reflected left ventricular morphology. Faculty of Veterinary Medicine 2023-05 2023-05-14 /pmc/articles/PMC10257462/ /pubmed/37304609 http://dx.doi.org/10.5455/OVJ.2023.v13.i5.13 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Ogawa, Mizuki
Kojima, Yuki
Ishizaka, Mio
Miyakawa, Hirosumi
Hsu, Huai-hsun
Miyagawa, Yuichi
Takemura, Naoyuki
Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
title Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
title_full Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
title_fullStr Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
title_full_unstemmed Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
title_short Plasma N-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
title_sort plasma n-terminal pro-atrial natriuretic peptide concentrations are affected by dehydration in healthy dogs
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257462/
https://www.ncbi.nlm.nih.gov/pubmed/37304609
http://dx.doi.org/10.5455/OVJ.2023.v13.i5.13
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