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Targeting the ADPKD methylome using nanoparticle-mediated combination therapy

DNA methylation aberrancies are found in autosomal dominant polycystic kidney disease (ADPKD), which suggests the methylome to be a promising therapeutic target. However, the impact of combining DNA methylation inhibitors (DNMTi) and ADPKD drugs in treating ADPKD and on disease-associated methylatio...

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Detalles Bibliográficos
Autores principales:	Trinh, Annie, Huang, Yi, Shao, Hanjuan, Ram, Aparna, Morival, Julien, Wang, Jonathan, Chung, Eun Ji, Downing, Timothy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AIP Publishing LLC 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257530/ https://www.ncbi.nlm.nih.gov/pubmed/37305656 http://dx.doi.org/10.1063/5.0151408

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