Metformin-Induced Acute Hepatitis

Metformin is considered an initial oral pharmacotherapy of choice for treating hyperglycemia in type 2 diabetes mellitus (T2DM). Although safe in the vast majority of the population, rare side effects will come to light as the prevalence of T2DM continues to rise. We present a rare case of metformin...

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Autores principales: Mian, Arooj, Bani Fawwaz, Baha Aldeen, Singh, Gurdeep, Farooq, Aimen, Koteish, Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257557/
https://www.ncbi.nlm.nih.gov/pubmed/37309348
http://dx.doi.org/10.7759/cureus.38908
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author Mian, Arooj
Bani Fawwaz, Baha Aldeen
Singh, Gurdeep
Farooq, Aimen
Koteish, Ayman
author_facet Mian, Arooj
Bani Fawwaz, Baha Aldeen
Singh, Gurdeep
Farooq, Aimen
Koteish, Ayman
author_sort Mian, Arooj
collection PubMed
description Metformin is considered an initial oral pharmacotherapy of choice for treating hyperglycemia in type 2 diabetes mellitus (T2DM). Although safe in the vast majority of the population, rare side effects will come to light as the prevalence of T2DM continues to rise. We present a rare case of metformin-induced hepatotoxicity and possibly the first reported case of dose-dependent metformin-induced hepatotoxicity. This case report aims to make clinicians aware of this infrequent yet significant adverse reaction that can arise with metformin therapy.
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spelling pubmed-102575572023-06-12 Metformin-Induced Acute Hepatitis Mian, Arooj Bani Fawwaz, Baha Aldeen Singh, Gurdeep Farooq, Aimen Koteish, Ayman Cureus Endocrinology/Diabetes/Metabolism Metformin is considered an initial oral pharmacotherapy of choice for treating hyperglycemia in type 2 diabetes mellitus (T2DM). Although safe in the vast majority of the population, rare side effects will come to light as the prevalence of T2DM continues to rise. We present a rare case of metformin-induced hepatotoxicity and possibly the first reported case of dose-dependent metformin-induced hepatotoxicity. This case report aims to make clinicians aware of this infrequent yet significant adverse reaction that can arise with metformin therapy. Cureus 2023-05-11 /pmc/articles/PMC10257557/ /pubmed/37309348 http://dx.doi.org/10.7759/cureus.38908 Text en Copyright © 2023, Mian et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Mian, Arooj
Bani Fawwaz, Baha Aldeen
Singh, Gurdeep
Farooq, Aimen
Koteish, Ayman
Metformin-Induced Acute Hepatitis
title Metformin-Induced Acute Hepatitis
title_full Metformin-Induced Acute Hepatitis
title_fullStr Metformin-Induced Acute Hepatitis
title_full_unstemmed Metformin-Induced Acute Hepatitis
title_short Metformin-Induced Acute Hepatitis
title_sort metformin-induced acute hepatitis
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257557/
https://www.ncbi.nlm.nih.gov/pubmed/37309348
http://dx.doi.org/10.7759/cureus.38908
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AT singhgurdeep metformininducedacutehepatitis
AT farooqaimen metformininducedacutehepatitis
AT koteishayman metformininducedacutehepatitis

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