The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

Pediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease characterized by a high prevalence of gene fusions as driver mutations. Despite the improvement of survival in the last years, about 50% of patients still experience a relapse. It is not possible to improve prognosis only wit...

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Detalles Bibliográficos
Autores principales: Domingo-Reinés, Joan, Montes, Rosa, Garcia-Moreno, Adrián, Gallardo, Amador, Sanchez-Manas, Jose Manuel, Ellson, Iván, Lamolda, Mar, Calabro, Chiara, López-Escamez, Jose Antonio, Catalina, Purificación, Carmona-Sáez, Pedro, Real, Pedro J., Landeira, David, Ramos-Mejia, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257648/
https://www.ncbi.nlm.nih.gov/pubmed/37301844
http://dx.doi.org/10.1038/s41419-023-05870-5

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