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Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort

Insulin resistance (IR) is defined as the subnormal response to insulin action on its target tissues. Studies suggest that IR may increase the risk of hypertension, but the results are inconsistent and it is not known whether such an effect is independent of overweight/obesity. We aimed to evaluate...

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Autores principales: Castro, Luísa, Brant, Luísa, Diniz, Maria de Fátima, Lotufo, Paulo, Bensenor, Isabela Judith, Chor, Dora, Griep, Rosane, Barreto, Sandhi Maria, Ribeiro, Antonio Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257662/
https://www.ncbi.nlm.nih.gov/pubmed/37301876
http://dx.doi.org/10.1038/s41598-023-35298-y
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author Castro, Luísa
Brant, Luísa
Diniz, Maria de Fátima
Lotufo, Paulo
Bensenor, Isabela Judith
Chor, Dora
Griep, Rosane
Barreto, Sandhi Maria
Ribeiro, Antonio Luiz
author_facet Castro, Luísa
Brant, Luísa
Diniz, Maria de Fátima
Lotufo, Paulo
Bensenor, Isabela Judith
Chor, Dora
Griep, Rosane
Barreto, Sandhi Maria
Ribeiro, Antonio Luiz
author_sort Castro, Luísa
collection PubMed
description Insulin resistance (IR) is defined as the subnormal response to insulin action on its target tissues. Studies suggest that IR may increase the risk of hypertension, but the results are inconsistent and it is not known whether such an effect is independent of overweight/obesity. We aimed to evaluate the association between IR and the incidence of prehypertension and hypertension in the Brazilian population and whether this association is independent of overweight/obesity. In 4717 participants of the Brazilian Longitudinal Study of Adult’s Health (ELSA-Brasil), free of diabetes and cardiovascular disease at baseline (2008–2010), we investigated the incidence of prehypertension and hypertension after a mean follow-up of 3.8 ± 0.5 years. Insulin resistance at baseline was assessed by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index, defined if above the 75th percentile. The risk of IR-associated prehypertension/hypertension was estimated by multinomial logistic regression after adjustment for confounding factors. Secondary analysis were stratified by body mass index. The mean (SD) age of participants was 48 (8) years, 67% were women. The 75th percentile of HOMA-IR at baseline was 2.85. The presence of IR increased the chance of developing prehypertension by 51% (95% CI 1.28–1.79) and hypertension by 150% (95% CI 1.48–4.23). In individuals with BMI < 25 kg/m(2), the presence of IR remained associated with the incidence of prehypertension (OR 1.41; 95% CI 1.01–1.98) and hypertension (OR 3.15; 95% CI 1.27–7.81). In conclusion, our results suggest that IR is a risk factor for hypertension, regardless of the presence of overweight or obesity.
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spelling pubmed-102576622023-06-12 Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort Castro, Luísa Brant, Luísa Diniz, Maria de Fátima Lotufo, Paulo Bensenor, Isabela Judith Chor, Dora Griep, Rosane Barreto, Sandhi Maria Ribeiro, Antonio Luiz Sci Rep Article Insulin resistance (IR) is defined as the subnormal response to insulin action on its target tissues. Studies suggest that IR may increase the risk of hypertension, but the results are inconsistent and it is not known whether such an effect is independent of overweight/obesity. We aimed to evaluate the association between IR and the incidence of prehypertension and hypertension in the Brazilian population and whether this association is independent of overweight/obesity. In 4717 participants of the Brazilian Longitudinal Study of Adult’s Health (ELSA-Brasil), free of diabetes and cardiovascular disease at baseline (2008–2010), we investigated the incidence of prehypertension and hypertension after a mean follow-up of 3.8 ± 0.5 years. Insulin resistance at baseline was assessed by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index, defined if above the 75th percentile. The risk of IR-associated prehypertension/hypertension was estimated by multinomial logistic regression after adjustment for confounding factors. Secondary analysis were stratified by body mass index. The mean (SD) age of participants was 48 (8) years, 67% were women. The 75th percentile of HOMA-IR at baseline was 2.85. The presence of IR increased the chance of developing prehypertension by 51% (95% CI 1.28–1.79) and hypertension by 150% (95% CI 1.48–4.23). In individuals with BMI < 25 kg/m(2), the presence of IR remained associated with the incidence of prehypertension (OR 1.41; 95% CI 1.01–1.98) and hypertension (OR 3.15; 95% CI 1.27–7.81). In conclusion, our results suggest that IR is a risk factor for hypertension, regardless of the presence of overweight or obesity. Nature Publishing Group UK 2023-06-10 /pmc/articles/PMC10257662/ /pubmed/37301876 http://dx.doi.org/10.1038/s41598-023-35298-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Castro, Luísa
Brant, Luísa
Diniz, Maria de Fátima
Lotufo, Paulo
Bensenor, Isabela Judith
Chor, Dora
Griep, Rosane
Barreto, Sandhi Maria
Ribeiro, Antonio Luiz
Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort
title Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort
title_full Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort
title_fullStr Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort
title_full_unstemmed Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort
title_short Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort
title_sort association of hypertension and insulin resistance in individuals free of diabetes in the elsa-brasil cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257662/
https://www.ncbi.nlm.nih.gov/pubmed/37301876
http://dx.doi.org/10.1038/s41598-023-35298-y
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