A pilot study of lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell therapy in patients with advanced solid tumors

Currently, the optimal lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell (Neo-T) therapy has yet to be determined. We report a single-arm, open-label and non-randomized phase 1 study (NCT02959905) of Neo-T therapy with lymphodepletion at various...

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Detalles Bibliográficos
Autores principales: Li, Dandan, Chen, Chao, Li, Jingjing, Yue, Jianhui, Ding, Ya, Wang, Hailun, Liang, Zhaoduan, Zhang, Le, Qiu, Si, Liu, Geng, Gao, Yan, Huang, Ying, Li, Dongli, Zhang, Rong, Liu, Wei, Wen, Xizhi, Li, Bo, Zhang, Xiaoshi, Zhang, Xi, Xu, Rui-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257664/
https://www.ncbi.nlm.nih.gov/pubmed/37301885
http://dx.doi.org/10.1038/s41467-023-39225-7

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