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Scarless wound healing programmed by core-shell microneedles
Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257705/ https://www.ncbi.nlm.nih.gov/pubmed/37301874 http://dx.doi.org/10.1038/s41467-023-39129-6 |
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author | Zhang, Ying Wang, Shenqiang Yang, Yinxian Zhao, Sheng You, Jiahuan Wang, Junxia Cai, Jingwei Wang, Hao Wang, Jie Zhang, Wei Yu, Jicheng Han, Chunmao Zhang, Yuqi Gu, Zhen |
author_facet | Zhang, Ying Wang, Shenqiang Yang, Yinxian Zhao, Sheng You, Jiahuan Wang, Junxia Cai, Jingwei Wang, Hao Wang, Jie Zhang, Wei Yu, Jicheng Han, Chunmao Zhang, Yuqi Gu, Zhen |
author_sort | Zhang, Ying |
collection | PubMed |
description | Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models. |
format | Online Article Text |
id | pubmed-10257705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102577052023-06-12 Scarless wound healing programmed by core-shell microneedles Zhang, Ying Wang, Shenqiang Yang, Yinxian Zhao, Sheng You, Jiahuan Wang, Junxia Cai, Jingwei Wang, Hao Wang, Jie Zhang, Wei Yu, Jicheng Han, Chunmao Zhang, Yuqi Gu, Zhen Nat Commun Article Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models. Nature Publishing Group UK 2023-06-10 /pmc/articles/PMC10257705/ /pubmed/37301874 http://dx.doi.org/10.1038/s41467-023-39129-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Ying Wang, Shenqiang Yang, Yinxian Zhao, Sheng You, Jiahuan Wang, Junxia Cai, Jingwei Wang, Hao Wang, Jie Zhang, Wei Yu, Jicheng Han, Chunmao Zhang, Yuqi Gu, Zhen Scarless wound healing programmed by core-shell microneedles |
title | Scarless wound healing programmed by core-shell microneedles |
title_full | Scarless wound healing programmed by core-shell microneedles |
title_fullStr | Scarless wound healing programmed by core-shell microneedles |
title_full_unstemmed | Scarless wound healing programmed by core-shell microneedles |
title_short | Scarless wound healing programmed by core-shell microneedles |
title_sort | scarless wound healing programmed by core-shell microneedles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257705/ https://www.ncbi.nlm.nih.gov/pubmed/37301874 http://dx.doi.org/10.1038/s41467-023-39129-6 |
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