Flow rate resonance of actively deforming particles

Lymphoid organs are unusual multicellular tissues: they are densely packed, but the lymphocytes trafficking through them are actively moving. We hypothesize that the intriguing ability of lymphocytes to avoid jamming and clogging is in part attributable to the dynamic shape changes that cells underg...

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Autores principales: Parisi, Daniel R., Wiebke, Lucas E., Mandl, Judith N., Textor, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257709/
https://www.ncbi.nlm.nih.gov/pubmed/37301896
http://dx.doi.org/10.1038/s41598-023-36182-5
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author Parisi, Daniel R.
Wiebke, Lucas E.
Mandl, Judith N.
Textor, Johannes
author_facet Parisi, Daniel R.
Wiebke, Lucas E.
Mandl, Judith N.
Textor, Johannes
author_sort Parisi, Daniel R.
collection PubMed
description Lymphoid organs are unusual multicellular tissues: they are densely packed, but the lymphocytes trafficking through them are actively moving. We hypothesize that the intriguing ability of lymphocytes to avoid jamming and clogging is in part attributable to the dynamic shape changes that cells undergo when they move. In this work, we test this hypothesis by investigating an idealized system, namely, the flow of self-propelled, oscillating particles passing through a narrow constriction in two dimensions (2D), using numerical simulations. We found that deformation allows particles with these properties to flow through a narrow constriction in conditions when non-deformable particles would not be able to do so. Such a flowing state requires the amplitude and frequency of oscillations to exceed threshold values. Moreover, a resonance leading to the maximum flow rate was found when the oscillation frequency matched the natural frequency of the particle related to its elastic stiffness. To our knowledge, this phenomenon has not been described previously. Our findings could have important implications for understanding and controlling flow in a variety of systems in addition to lymphoid organs, such as granular flows subjected to vibration.
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spelling pubmed-102577092023-06-12 Flow rate resonance of actively deforming particles Parisi, Daniel R. Wiebke, Lucas E. Mandl, Judith N. Textor, Johannes Sci Rep Article Lymphoid organs are unusual multicellular tissues: they are densely packed, but the lymphocytes trafficking through them are actively moving. We hypothesize that the intriguing ability of lymphocytes to avoid jamming and clogging is in part attributable to the dynamic shape changes that cells undergo when they move. In this work, we test this hypothesis by investigating an idealized system, namely, the flow of self-propelled, oscillating particles passing through a narrow constriction in two dimensions (2D), using numerical simulations. We found that deformation allows particles with these properties to flow through a narrow constriction in conditions when non-deformable particles would not be able to do so. Such a flowing state requires the amplitude and frequency of oscillations to exceed threshold values. Moreover, a resonance leading to the maximum flow rate was found when the oscillation frequency matched the natural frequency of the particle related to its elastic stiffness. To our knowledge, this phenomenon has not been described previously. Our findings could have important implications for understanding and controlling flow in a variety of systems in addition to lymphoid organs, such as granular flows subjected to vibration. Nature Publishing Group UK 2023-06-10 /pmc/articles/PMC10257709/ /pubmed/37301896 http://dx.doi.org/10.1038/s41598-023-36182-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Parisi, Daniel R.
Wiebke, Lucas E.
Mandl, Judith N.
Textor, Johannes
Flow rate resonance of actively deforming particles
title Flow rate resonance of actively deforming particles
title_full Flow rate resonance of actively deforming particles
title_fullStr Flow rate resonance of actively deforming particles
title_full_unstemmed Flow rate resonance of actively deforming particles
title_short Flow rate resonance of actively deforming particles
title_sort flow rate resonance of actively deforming particles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257709/
https://www.ncbi.nlm.nih.gov/pubmed/37301896
http://dx.doi.org/10.1038/s41598-023-36182-5
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