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Molecular prognostic factors in colorectal cancer: 5-year follow-up
Colorectal cancer (CRC) is a frequently diagnosed and lethal disease. The risk of developing CRC is determined by environmental and genetic factors. Surgical treatment is the main curative modality for patients with CRC up to stage III. In recent years, a special place has been given to biological a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257784/ https://www.ncbi.nlm.nih.gov/pubmed/37128793 http://dx.doi.org/10.47162/RJME.64.1.08 |
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author | Ciobanu, Alina Elena Pîrvu, Daniel-Cristian Mărginean, Cristina Maria Dijmărescu, Anda Lorena Muñoz-Groza, Adriana-Estefa Meşină, Cristian Bălşeanu, Tudor-Adrian Băleanu, Vlad Dumitru Ţenea-Cojan, Tiberiu Ştefăniţă Ciobanu, Daniela |
author_facet | Ciobanu, Alina Elena Pîrvu, Daniel-Cristian Mărginean, Cristina Maria Dijmărescu, Anda Lorena Muñoz-Groza, Adriana-Estefa Meşină, Cristian Bălşeanu, Tudor-Adrian Băleanu, Vlad Dumitru Ţenea-Cojan, Tiberiu Ştefăniţă Ciobanu, Daniela |
author_sort | Ciobanu, Alina Elena |
collection | PubMed |
description | Colorectal cancer (CRC) is a frequently diagnosed and lethal disease. The risk of developing CRC is determined by environmental and genetic factors. Surgical treatment is the main curative modality for patients with CRC up to stage III. In recent years, a special place has been given to biological agents used as targeted therapy following the genetic analysis of the tumor: Bevacizumab (Avastin), Cetuximab (Erbitux), Ziv-aflibercept (Zaltrap). We present a study based on 46 colorectal tumor resection specimens from patients operated for CRC in the Surgery Departments of the Emergency County Clinical Hospital of Craiova, Romania. Histopathological examination and immunohistochemistry staining of tissue sections were performed to determine the degree of aggressiveness. Using the Kaplan–Meier test, we calculated the correlation coefficient between survival time and immunohistochemical prognostic factors. The patients were followed for 60 months postoperatively. |
format | Online Article Text |
id | pubmed-10257784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest |
record_format | MEDLINE/PubMed |
spelling | pubmed-102577842023-06-12 Molecular prognostic factors in colorectal cancer: 5-year follow-up Ciobanu, Alina Elena Pîrvu, Daniel-Cristian Mărginean, Cristina Maria Dijmărescu, Anda Lorena Muñoz-Groza, Adriana-Estefa Meşină, Cristian Bălşeanu, Tudor-Adrian Băleanu, Vlad Dumitru Ţenea-Cojan, Tiberiu Ştefăniţă Ciobanu, Daniela Rom J Morphol Embryol Original Paper Colorectal cancer (CRC) is a frequently diagnosed and lethal disease. The risk of developing CRC is determined by environmental and genetic factors. Surgical treatment is the main curative modality for patients with CRC up to stage III. In recent years, a special place has been given to biological agents used as targeted therapy following the genetic analysis of the tumor: Bevacizumab (Avastin), Cetuximab (Erbitux), Ziv-aflibercept (Zaltrap). We present a study based on 46 colorectal tumor resection specimens from patients operated for CRC in the Surgery Departments of the Emergency County Clinical Hospital of Craiova, Romania. Histopathological examination and immunohistochemistry staining of tissue sections were performed to determine the degree of aggressiveness. Using the Kaplan–Meier test, we calculated the correlation coefficient between survival time and immunohistochemical prognostic factors. The patients were followed for 60 months postoperatively. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2023 2023-03-31 /pmc/articles/PMC10257784/ /pubmed/37128793 http://dx.doi.org/10.47162/RJME.64.1.08 Text en Copyright © 2023, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. |
spellingShingle | Original Paper Ciobanu, Alina Elena Pîrvu, Daniel-Cristian Mărginean, Cristina Maria Dijmărescu, Anda Lorena Muñoz-Groza, Adriana-Estefa Meşină, Cristian Bălşeanu, Tudor-Adrian Băleanu, Vlad Dumitru Ţenea-Cojan, Tiberiu Ştefăniţă Ciobanu, Daniela Molecular prognostic factors in colorectal cancer: 5-year follow-up |
title | Molecular prognostic factors in colorectal cancer: 5-year follow-up |
title_full | Molecular prognostic factors in colorectal cancer: 5-year follow-up |
title_fullStr | Molecular prognostic factors in colorectal cancer: 5-year follow-up |
title_full_unstemmed | Molecular prognostic factors in colorectal cancer: 5-year follow-up |
title_short | Molecular prognostic factors in colorectal cancer: 5-year follow-up |
title_sort | molecular prognostic factors in colorectal cancer: 5-year follow-up |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257784/ https://www.ncbi.nlm.nih.gov/pubmed/37128793 http://dx.doi.org/10.47162/RJME.64.1.08 |
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