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Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients
PURPOSE: In COPD, exacerbation of the disorder causes a deterioration in the quality-of-life and worsens respiratory dysfunction, leading to a poor prognosis. In recent years, nutritional indices have been reported as significant prognostic factors in various chronic diseases. However, the relations...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257926/ https://www.ncbi.nlm.nih.gov/pubmed/37309393 http://dx.doi.org/10.2147/COPD.S385374 |
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author | Suzuki, Eiko Kawata, Naoko Shimada, Ayako Sato, Hirotaka Anazawa, Rie Suzuki, Masaki Shiko, Yuki Yamamoto, Mayumi Ikari, Jun Tatsumi, Koichiro Suzuki, Takuji |
author_facet | Suzuki, Eiko Kawata, Naoko Shimada, Ayako Sato, Hirotaka Anazawa, Rie Suzuki, Masaki Shiko, Yuki Yamamoto, Mayumi Ikari, Jun Tatsumi, Koichiro Suzuki, Takuji |
author_sort | Suzuki, Eiko |
collection | PubMed |
description | PURPOSE: In COPD, exacerbation of the disorder causes a deterioration in the quality-of-life and worsens respiratory dysfunction, leading to a poor prognosis. In recent years, nutritional indices have been reported as significant prognostic factors in various chronic diseases. However, the relationship between nutritional indicators and prognosis in elderly subjects with COPD has not been investigated. PATIENTS AND METHODS: We enrolled 91 subjects who received COPD assessment tests (CAT), spirometry, blood tests, and multidetector computed tomography (MDCT). We divided the subjects into two groups according to age (<75 years (n=57) and ≥ 75 years (n=34)). The prognostic nutritional index (PNI) was used to assess immune-nutritional status and was calculated as 10 x serum albumin + 0.005 x total lymphocyte count. We then examined the relationship between PNI and clinical parameters, including exacerbation events. RESULTS: There was no significant correlation between the PNI and CAT, the FEV(1)%pred, or low attenuation volume percentage (LAV%). In the elderly group, there were significant differences between the groups with or without exacerbation in the CAT and PNI (p=0.008, p=0.004, respectively). FEV(1)%pred, neutrophil-to-lymphocyte ratio (NLR) and LAV% did not differ between the two groups. The analytical model combining CAT and PNI improved the prediction of exacerbations in the elderly subjects (p=0.0068). CONCLUSION: In elderly subjects with COPD, CAT were associated significantly with the risk of COPD exacerbation, with PNI also a potential predictor. The combined assessment of CAT and PNI may be a useful prognostic tool in subjects with COPD. |
format | Online Article Text |
id | pubmed-10257926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-102579262023-06-12 Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients Suzuki, Eiko Kawata, Naoko Shimada, Ayako Sato, Hirotaka Anazawa, Rie Suzuki, Masaki Shiko, Yuki Yamamoto, Mayumi Ikari, Jun Tatsumi, Koichiro Suzuki, Takuji Int J Chron Obstruct Pulmon Dis Original Research PURPOSE: In COPD, exacerbation of the disorder causes a deterioration in the quality-of-life and worsens respiratory dysfunction, leading to a poor prognosis. In recent years, nutritional indices have been reported as significant prognostic factors in various chronic diseases. However, the relationship between nutritional indicators and prognosis in elderly subjects with COPD has not been investigated. PATIENTS AND METHODS: We enrolled 91 subjects who received COPD assessment tests (CAT), spirometry, blood tests, and multidetector computed tomography (MDCT). We divided the subjects into two groups according to age (<75 years (n=57) and ≥ 75 years (n=34)). The prognostic nutritional index (PNI) was used to assess immune-nutritional status and was calculated as 10 x serum albumin + 0.005 x total lymphocyte count. We then examined the relationship between PNI and clinical parameters, including exacerbation events. RESULTS: There was no significant correlation between the PNI and CAT, the FEV(1)%pred, or low attenuation volume percentage (LAV%). In the elderly group, there were significant differences between the groups with or without exacerbation in the CAT and PNI (p=0.008, p=0.004, respectively). FEV(1)%pred, neutrophil-to-lymphocyte ratio (NLR) and LAV% did not differ between the two groups. The analytical model combining CAT and PNI improved the prediction of exacerbations in the elderly subjects (p=0.0068). CONCLUSION: In elderly subjects with COPD, CAT were associated significantly with the risk of COPD exacerbation, with PNI also a potential predictor. The combined assessment of CAT and PNI may be a useful prognostic tool in subjects with COPD. Dove 2023-06-07 /pmc/articles/PMC10257926/ /pubmed/37309393 http://dx.doi.org/10.2147/COPD.S385374 Text en © 2023 Suzuki et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Suzuki, Eiko Kawata, Naoko Shimada, Ayako Sato, Hirotaka Anazawa, Rie Suzuki, Masaki Shiko, Yuki Yamamoto, Mayumi Ikari, Jun Tatsumi, Koichiro Suzuki, Takuji Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients |
title | Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients |
title_full | Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients |
title_fullStr | Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients |
title_full_unstemmed | Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients |
title_short | Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients |
title_sort | prognostic nutritional index (pni) as a potential prognostic tool for exacerbation of copd in elderly patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257926/ https://www.ncbi.nlm.nih.gov/pubmed/37309393 http://dx.doi.org/10.2147/COPD.S385374 |
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