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Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda

BACKGROUND: Malaria remains the leading cause of death in sub-Saharan Africa. Although recent developments such as malaria vaccine trials inspire optimism, the search for novel antimalarial drugs is urgently needed to control the mounting resistance of Plasmodium species to the available therapies....

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Autores principales: Tabuti, John R. S., Obakiro, Samuel Baker, Nabatanzi, Alice, Anywar, Godwin, Nambejja, Cissy, Mutyaba, Michael R., Omara, Timothy, Waako, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258082/
https://www.ncbi.nlm.nih.gov/pubmed/37303066
http://dx.doi.org/10.1186/s41182-023-00526-8
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author Tabuti, John R. S.
Obakiro, Samuel Baker
Nabatanzi, Alice
Anywar, Godwin
Nambejja, Cissy
Mutyaba, Michael R.
Omara, Timothy
Waako, Paul
author_facet Tabuti, John R. S.
Obakiro, Samuel Baker
Nabatanzi, Alice
Anywar, Godwin
Nambejja, Cissy
Mutyaba, Michael R.
Omara, Timothy
Waako, Paul
author_sort Tabuti, John R. S.
collection PubMed
description BACKGROUND: Malaria remains the leading cause of death in sub-Saharan Africa. Although recent developments such as malaria vaccine trials inspire optimism, the search for novel antimalarial drugs is urgently needed to control the mounting resistance of Plasmodium species to the available therapies. The present study was conducted to document ethnobotanical knowledge on the plants used to treat symptoms of malaria in Tororo district, a malaria-endemic region of Eastern Uganda. METHODS: An ethnobotanical study was carried out between February 2020 and September 2020 in 12 randomly selected villages of Tororo district. In total, 151 respondents (21 herbalists and 130 non-herbalists) were selected using multistage random sampling method. Their awareness of malaria, treatment-seeking behaviour and herbal treatment practices were obtained using semi-structured questionnaires and focus group discussions. Data were analysed using descriptive statistics, paired comparison, preference ranking and informant consensus factor. RESULTS: A total of 45 plant species belonging to 26 families and 44 genera were used in the preparation of herbal medicines for management of malaria and its symptoms. The most frequently mentioned plant species were Vernonia amygdalina, Chamaecrista nigricans, Aloe nobilis, Warburgia ugandensis, Abrus precatorius, Kedrostis foetidissima, Senna occidentalis, Azadirachta indica and Mangifera indica. Leaves (67.3%) were the most used plant part while maceration (56%) was the major method of herbal remedy preparation. Oral route was the predominant mode of administration with inconsistencies in the posology prescribed. CONCLUSION: This study showed that the identified medicinal plants in Tororo district, Uganda, are potential sources of new antimalarial drugs. This provides a basis for investigating the antimalarial efficacy, phytochemistry and toxicity of the unstudied species with high percentage use values to validate their use in the management of malaria. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41182-023-00526-8.
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spelling pubmed-102580822023-06-13 Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda Tabuti, John R. S. Obakiro, Samuel Baker Nabatanzi, Alice Anywar, Godwin Nambejja, Cissy Mutyaba, Michael R. Omara, Timothy Waako, Paul Trop Med Health Research BACKGROUND: Malaria remains the leading cause of death in sub-Saharan Africa. Although recent developments such as malaria vaccine trials inspire optimism, the search for novel antimalarial drugs is urgently needed to control the mounting resistance of Plasmodium species to the available therapies. The present study was conducted to document ethnobotanical knowledge on the plants used to treat symptoms of malaria in Tororo district, a malaria-endemic region of Eastern Uganda. METHODS: An ethnobotanical study was carried out between February 2020 and September 2020 in 12 randomly selected villages of Tororo district. In total, 151 respondents (21 herbalists and 130 non-herbalists) were selected using multistage random sampling method. Their awareness of malaria, treatment-seeking behaviour and herbal treatment practices were obtained using semi-structured questionnaires and focus group discussions. Data were analysed using descriptive statistics, paired comparison, preference ranking and informant consensus factor. RESULTS: A total of 45 plant species belonging to 26 families and 44 genera were used in the preparation of herbal medicines for management of malaria and its symptoms. The most frequently mentioned plant species were Vernonia amygdalina, Chamaecrista nigricans, Aloe nobilis, Warburgia ugandensis, Abrus precatorius, Kedrostis foetidissima, Senna occidentalis, Azadirachta indica and Mangifera indica. Leaves (67.3%) were the most used plant part while maceration (56%) was the major method of herbal remedy preparation. Oral route was the predominant mode of administration with inconsistencies in the posology prescribed. CONCLUSION: This study showed that the identified medicinal plants in Tororo district, Uganda, are potential sources of new antimalarial drugs. This provides a basis for investigating the antimalarial efficacy, phytochemistry and toxicity of the unstudied species with high percentage use values to validate their use in the management of malaria. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41182-023-00526-8. BioMed Central 2023-06-12 /pmc/articles/PMC10258082/ /pubmed/37303066 http://dx.doi.org/10.1186/s41182-023-00526-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Tabuti, John R. S.
Obakiro, Samuel Baker
Nabatanzi, Alice
Anywar, Godwin
Nambejja, Cissy
Mutyaba, Michael R.
Omara, Timothy
Waako, Paul
Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda
title Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda
title_full Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda
title_fullStr Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda
title_full_unstemmed Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda
title_short Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda
title_sort medicinal plants used for treatment of malaria by indigenous communities of tororo district, eastern uganda
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258082/
https://www.ncbi.nlm.nih.gov/pubmed/37303066
http://dx.doi.org/10.1186/s41182-023-00526-8
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