Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome

A 76-year-old woman was admitted to our hospital for refractory diarrhea with a poor antidiarrheal effect. Chest and abdominal computed tomography revealed a 24×22-mm mass in the left upper lobe of lung and multiple masses in the liver. Urine 5-Hydroxy indol acetic acid was markedly elevated. A live...

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Autores principales: Yamamoto, Makoto, Ito, Renma, Tsujibata, Akihiko, Morita, Hiroko, Yoneda, Taro, Matano, Yutaka, Higashikata, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258109/
https://www.ncbi.nlm.nih.gov/pubmed/36198589
http://dx.doi.org/10.2169/internalmedicine.0099-22
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author Yamamoto, Makoto
Ito, Renma
Tsujibata, Akihiko
Morita, Hiroko
Yoneda, Taro
Matano, Yutaka
Higashikata, Toshinori
author_facet Yamamoto, Makoto
Ito, Renma
Tsujibata, Akihiko
Morita, Hiroko
Yoneda, Taro
Matano, Yutaka
Higashikata, Toshinori
author_sort Yamamoto, Makoto
collection PubMed
description A 76-year-old woman was admitted to our hospital for refractory diarrhea with a poor antidiarrheal effect. Chest and abdominal computed tomography revealed a 24×22-mm mass in the left upper lobe of lung and multiple masses in the liver. Urine 5-Hydroxy indol acetic acid was markedly elevated. A liver biopsy revealed large-cell neuroendocrine carcinoma with serotonin production, suggestive of a lung origin, and a lung biopsy revealed combined large-cell neuroendocrine carcinoma and squamous cell carcinoma. Therefore, we made a definitive diagnosis of carcinoid syndrome caused by large-cell neuroendocrine carcinoma of the lung. Although chemotherapy was performed after diagnosis, the patient died 50 days postadmission.
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spelling pubmed-102581092023-06-13 Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome Yamamoto, Makoto Ito, Renma Tsujibata, Akihiko Morita, Hiroko Yoneda, Taro Matano, Yutaka Higashikata, Toshinori Intern Med Case Report A 76-year-old woman was admitted to our hospital for refractory diarrhea with a poor antidiarrheal effect. Chest and abdominal computed tomography revealed a 24×22-mm mass in the left upper lobe of lung and multiple masses in the liver. Urine 5-Hydroxy indol acetic acid was markedly elevated. A liver biopsy revealed large-cell neuroendocrine carcinoma with serotonin production, suggestive of a lung origin, and a lung biopsy revealed combined large-cell neuroendocrine carcinoma and squamous cell carcinoma. Therefore, we made a definitive diagnosis of carcinoid syndrome caused by large-cell neuroendocrine carcinoma of the lung. Although chemotherapy was performed after diagnosis, the patient died 50 days postadmission. The Japanese Society of Internal Medicine 2022-10-05 2023-05-15 /pmc/articles/PMC10258109/ /pubmed/36198589 http://dx.doi.org/10.2169/internalmedicine.0099-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamamoto, Makoto
Ito, Renma
Tsujibata, Akihiko
Morita, Hiroko
Yoneda, Taro
Matano, Yutaka
Higashikata, Toshinori
Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome
title Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome
title_full Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome
title_fullStr Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome
title_full_unstemmed Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome
title_short Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome
title_sort large-cell neuroendocrine carcinoma of the lung with carcinoid syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258109/
https://www.ncbi.nlm.nih.gov/pubmed/36198589
http://dx.doi.org/10.2169/internalmedicine.0099-22
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