Identification of novel p-cresol inhibitors that reduce Clostridioides difficile’s ability to compete with species of the gut microbiome

Treatment of Clostridioides difficile infection (CDI) is expensive and complex, with a high proportion of patients suffering infection relapse (20–35%), and some having multiple relapses. A healthy, unperturbed gut microbiome provides colonisation resistance against CDI through competition for nutri...

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Detalles Bibliográficos
Autores principales: Harrison, Mark A., Farthing, Rebecca J., Allen, Nyasha, Ahern, Lucy M., Birchall, Kristian, Bond, Michael, Kaur, Harparkash, Wren, Brendan W., Bergeron, Julien R. C., Dawson, Lisa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258198/
https://www.ncbi.nlm.nih.gov/pubmed/37303029
http://dx.doi.org/10.1038/s41598-023-32656-8

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