Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke

Despite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functiona...

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Detalles Bibliográficos
Autores principales: Biose, Ifechukwude Joachim, Rutkai, Ibolya, Clossen, Bryan, Gage, Gary, Schechtman, Kenneth, Adkisson, H. Davis, Bix, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258221/
https://www.ncbi.nlm.nih.gov/pubmed/36508132
http://dx.doi.org/10.1007/s12975-022-01089-2

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