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Orbital lymphocyte populations in three states of thyroid eye disease

PURPOSE: We report histopathologic orbital tissue analysis from three patients with thyroid eye disease (TED) – active, chronic, and post-teprotumumab to better characterize orbital cellular populations in these varying states of TED. OBSERVATIONS: Orbital tissues in TED demonstrate minimal lymphocy...

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Detalles Bibliográficos
Autores principales: Griffin, Shane M., Silkiss, Rona Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258238/
https://www.ncbi.nlm.nih.gov/pubmed/37312678
http://dx.doi.org/10.1016/j.ajoc.2023.101865
Descripción
Sumario:PURPOSE: We report histopathologic orbital tissue analysis from three patients with thyroid eye disease (TED) – active, chronic, and post-teprotumumab to better characterize orbital cellular populations in these varying states of TED. OBSERVATIONS: Orbital tissues in TED demonstrate minimal lymphocytic infiltration in fat and Mueller's muscle. Following teprotumumab treatment, the tissues were devoid of lymphocytes with only perivascular cuffs of T-lymphocytes remaining in orbital fat. CONCLUSIONS AND IMPORTANCE: In active TED, post-teprotumumab treatment, and in quiescent TED, orbital fat may not show significant inflammatory infiltration. More work is warranted to characterize specific cellular effects of teprotumumab and other biologics.