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Orbital lymphocyte populations in three states of thyroid eye disease
PURPOSE: We report histopathologic orbital tissue analysis from three patients with thyroid eye disease (TED) – active, chronic, and post-teprotumumab to better characterize orbital cellular populations in these varying states of TED. OBSERVATIONS: Orbital tissues in TED demonstrate minimal lymphocy...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258238/ https://www.ncbi.nlm.nih.gov/pubmed/37312678 http://dx.doi.org/10.1016/j.ajoc.2023.101865 |
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author | Griffin, Shane M. Silkiss, Rona Z. |
author_facet | Griffin, Shane M. Silkiss, Rona Z. |
author_sort | Griffin, Shane M. |
collection | PubMed |
description | PURPOSE: We report histopathologic orbital tissue analysis from three patients with thyroid eye disease (TED) – active, chronic, and post-teprotumumab to better characterize orbital cellular populations in these varying states of TED. OBSERVATIONS: Orbital tissues in TED demonstrate minimal lymphocytic infiltration in fat and Mueller's muscle. Following teprotumumab treatment, the tissues were devoid of lymphocytes with only perivascular cuffs of T-lymphocytes remaining in orbital fat. CONCLUSIONS AND IMPORTANCE: In active TED, post-teprotumumab treatment, and in quiescent TED, orbital fat may not show significant inflammatory infiltration. More work is warranted to characterize specific cellular effects of teprotumumab and other biologics. |
format | Online Article Text |
id | pubmed-10258238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102582382023-06-13 Orbital lymphocyte populations in three states of thyroid eye disease Griffin, Shane M. Silkiss, Rona Z. Am J Ophthalmol Case Rep Case Report PURPOSE: We report histopathologic orbital tissue analysis from three patients with thyroid eye disease (TED) – active, chronic, and post-teprotumumab to better characterize orbital cellular populations in these varying states of TED. OBSERVATIONS: Orbital tissues in TED demonstrate minimal lymphocytic infiltration in fat and Mueller's muscle. Following teprotumumab treatment, the tissues were devoid of lymphocytes with only perivascular cuffs of T-lymphocytes remaining in orbital fat. CONCLUSIONS AND IMPORTANCE: In active TED, post-teprotumumab treatment, and in quiescent TED, orbital fat may not show significant inflammatory infiltration. More work is warranted to characterize specific cellular effects of teprotumumab and other biologics. Elsevier 2023-06-01 /pmc/articles/PMC10258238/ /pubmed/37312678 http://dx.doi.org/10.1016/j.ajoc.2023.101865 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Griffin, Shane M. Silkiss, Rona Z. Orbital lymphocyte populations in three states of thyroid eye disease |
title | Orbital lymphocyte populations in three states of thyroid eye disease |
title_full | Orbital lymphocyte populations in three states of thyroid eye disease |
title_fullStr | Orbital lymphocyte populations in three states of thyroid eye disease |
title_full_unstemmed | Orbital lymphocyte populations in three states of thyroid eye disease |
title_short | Orbital lymphocyte populations in three states of thyroid eye disease |
title_sort | orbital lymphocyte populations in three states of thyroid eye disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258238/ https://www.ncbi.nlm.nih.gov/pubmed/37312678 http://dx.doi.org/10.1016/j.ajoc.2023.101865 |
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