Trap and ambush therapy using sequential primary and tumor escape-selective oncolytic viruses

In multiple models of oncolytic virotherapy, it is common to see an early anti-tumor response followed by recurrence. We have previously shown that frontline treatment with oncolytic VSV-IFN-β induces APOBEC proteins, promoting the selection of specific mutations that allow tumor escape. Of these mu...

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Detalles Bibliográficos
Autores principales: Webb, Mason J., Kottke, Timothy, Kendall, Benjamin L., Swanson, Jack, Uzendu, Chisom, Tonne, Jason, Thompson, Jill, Metko, Muriel, Moore, Madelyn, Borad, Mitesh, Roberts, Lewis, Diaz, Rosa M., Olin, Michael, Borgatti, Antonella, Vile, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258242/
https://www.ncbi.nlm.nih.gov/pubmed/37313455
http://dx.doi.org/10.1016/j.omto.2023.05.006

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