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Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258315/ https://www.ncbi.nlm.nih.gov/pubmed/37313446 http://dx.doi.org/10.3389/fendo.2023.1192458 |
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author | Yi, Xuejie Yang, Yang Li, Tao Li, Menghuan Yao, Tingting Hu, Guangxuan Wan, Genmeng Chang, Bo |
author_facet | Yi, Xuejie Yang, Yang Li, Tao Li, Menghuan Yao, Tingting Hu, Guangxuan Wan, Genmeng Chang, Bo |
author_sort | Yi, Xuejie |
collection | PubMed |
description | Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in inflammation and oxidative stress. BAIBA is produced during exercise and is involved in the exercise response. No side effect has been observed in human and rat studies, suggesting that BAIBA can be developed as a pill that confers the benefits of exercise to subjects who, for some reason, are unable to do so. Further, BAIBA has been confirmed to participate in the diagnosis and prevention of diseases as an important biological marker of disease. The current review aimed to discuss the roles of BAIBA in multiple physiological processes and the possible pathways of its action, and assess the progress toward the development of BAIBA as an exercise mimic and biomarker with relevance to multiple disease states, in order to provide new ideas and strategies for basic research and disease prevention in related fields. |
format | Online Article Text |
id | pubmed-10258315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102583152023-06-13 Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill Yi, Xuejie Yang, Yang Li, Tao Li, Menghuan Yao, Tingting Hu, Guangxuan Wan, Genmeng Chang, Bo Front Endocrinol (Lausanne) Endocrinology Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in inflammation and oxidative stress. BAIBA is produced during exercise and is involved in the exercise response. No side effect has been observed in human and rat studies, suggesting that BAIBA can be developed as a pill that confers the benefits of exercise to subjects who, for some reason, are unable to do so. Further, BAIBA has been confirmed to participate in the diagnosis and prevention of diseases as an important biological marker of disease. The current review aimed to discuss the roles of BAIBA in multiple physiological processes and the possible pathways of its action, and assess the progress toward the development of BAIBA as an exercise mimic and biomarker with relevance to multiple disease states, in order to provide new ideas and strategies for basic research and disease prevention in related fields. Frontiers Media S.A. 2023-05-29 /pmc/articles/PMC10258315/ /pubmed/37313446 http://dx.doi.org/10.3389/fendo.2023.1192458 Text en Copyright © 2023 Yi, Yang, Li, Li, Yao, Hu, Wan and Chang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Yi, Xuejie Yang, Yang Li, Tao Li, Menghuan Yao, Tingting Hu, Guangxuan Wan, Genmeng Chang, Bo Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
title | Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
title_full | Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
title_fullStr | Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
title_full_unstemmed | Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
title_short | Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
title_sort | signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258315/ https://www.ncbi.nlm.nih.gov/pubmed/37313446 http://dx.doi.org/10.3389/fendo.2023.1192458 |
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