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Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill

Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in...

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Autores principales: Yi, Xuejie, Yang, Yang, Li, Tao, Li, Menghuan, Yao, Tingting, Hu, Guangxuan, Wan, Genmeng, Chang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258315/
https://www.ncbi.nlm.nih.gov/pubmed/37313446
http://dx.doi.org/10.3389/fendo.2023.1192458
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author Yi, Xuejie
Yang, Yang
Li, Tao
Li, Menghuan
Yao, Tingting
Hu, Guangxuan
Wan, Genmeng
Chang, Bo
author_facet Yi, Xuejie
Yang, Yang
Li, Tao
Li, Menghuan
Yao, Tingting
Hu, Guangxuan
Wan, Genmeng
Chang, Bo
author_sort Yi, Xuejie
collection PubMed
description Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in inflammation and oxidative stress. BAIBA is produced during exercise and is involved in the exercise response. No side effect has been observed in human and rat studies, suggesting that BAIBA can be developed as a pill that confers the benefits of exercise to subjects who, for some reason, are unable to do so. Further, BAIBA has been confirmed to participate in the diagnosis and prevention of diseases as an important biological marker of disease. The current review aimed to discuss the roles of BAIBA in multiple physiological processes and the possible pathways of its action, and assess the progress toward the development of BAIBA as an exercise mimic and biomarker with relevance to multiple disease states, in order to provide new ideas and strategies for basic research and disease prevention in related fields.
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spelling pubmed-102583152023-06-13 Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill Yi, Xuejie Yang, Yang Li, Tao Li, Menghuan Yao, Tingting Hu, Guangxuan Wan, Genmeng Chang, Bo Front Endocrinol (Lausanne) Endocrinology Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in inflammation and oxidative stress. BAIBA is produced during exercise and is involved in the exercise response. No side effect has been observed in human and rat studies, suggesting that BAIBA can be developed as a pill that confers the benefits of exercise to subjects who, for some reason, are unable to do so. Further, BAIBA has been confirmed to participate in the diagnosis and prevention of diseases as an important biological marker of disease. The current review aimed to discuss the roles of BAIBA in multiple physiological processes and the possible pathways of its action, and assess the progress toward the development of BAIBA as an exercise mimic and biomarker with relevance to multiple disease states, in order to provide new ideas and strategies for basic research and disease prevention in related fields. Frontiers Media S.A. 2023-05-29 /pmc/articles/PMC10258315/ /pubmed/37313446 http://dx.doi.org/10.3389/fendo.2023.1192458 Text en Copyright © 2023 Yi, Yang, Li, Li, Yao, Hu, Wan and Chang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yi, Xuejie
Yang, Yang
Li, Tao
Li, Menghuan
Yao, Tingting
Hu, Guangxuan
Wan, Genmeng
Chang, Bo
Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
title Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
title_full Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
title_fullStr Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
title_full_unstemmed Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
title_short Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
title_sort signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258315/
https://www.ncbi.nlm.nih.gov/pubmed/37313446
http://dx.doi.org/10.3389/fendo.2023.1192458
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