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Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral...

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Autores principales: Shao, Hao-Tian, Gao, Liang, Li, Hao-tian, Zhang, Mei, Chen, Jun-Cheng, Duan, Ming-Hui, Li, Ze-En, Dai, Yan, Li, Xing-Ping, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258491/
https://www.ncbi.nlm.nih.gov/pubmed/37270891
http://dx.doi.org/10.1016/j.psj.2023.102761
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author Shao, Hao-Tian
Gao, Liang
Li, Hao-tian
Zhang, Mei
Chen, Jun-Cheng
Duan, Ming-Hui
Li, Ze-En
Dai, Yan
Li, Xing-Ping
Yang, Fan
author_facet Shao, Hao-Tian
Gao, Liang
Li, Hao-tian
Zhang, Mei
Chen, Jun-Cheng
Duan, Ming-Hui
Li, Ze-En
Dai, Yan
Li, Xing-Ping
Yang, Fan
author_sort Shao, Hao-Tian
collection PubMed
description Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
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spelling pubmed-102584912023-06-13 Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses Shao, Hao-Tian Gao, Liang Li, Hao-tian Zhang, Mei Chen, Jun-Cheng Duan, Ming-Hui Li, Ze-En Dai, Yan Li, Xing-Ping Yang, Fan Poult Sci MICROBIOLOGY AND FOOD SAFETY Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety. Elsevier 2023-04-27 /pmc/articles/PMC10258491/ /pubmed/37270891 http://dx.doi.org/10.1016/j.psj.2023.102761 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle MICROBIOLOGY AND FOOD SAFETY
Shao, Hao-Tian
Gao, Liang
Li, Hao-tian
Zhang, Mei
Chen, Jun-Cheng
Duan, Ming-Hui
Li, Ze-En
Dai, Yan
Li, Xing-Ping
Yang, Fan
Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses
title Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses
title_full Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses
title_fullStr Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses
title_full_unstemmed Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses
title_short Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses
title_sort egg residue and depletion of meloxicam in jing hong laying hens following multiple oral doses
topic MICROBIOLOGY AND FOOD SAFETY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258491/
https://www.ncbi.nlm.nih.gov/pubmed/37270891
http://dx.doi.org/10.1016/j.psj.2023.102761
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