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A comprehensive review of cystic fibrosis in Africa and Asia

Cystic fibrosis (CF) was earlier thought to be a disease prevalent in the West among Caucasians. However, quite a number of recent studies have uncovered CF cases outside of this region, and reported hundreds of unique and novel variant forms of CFTR. Here, we discuss the evidence of CF in parts of...

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Autores principales: Abubakar Bobbo, Khadijat, Ahmad, Umar, Chau, De-Ming, Nordin, Norshariza, Abdullah, Syahril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258508/
https://www.ncbi.nlm.nih.gov/pubmed/37313453
http://dx.doi.org/10.1016/j.sjbs.2023.103685
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author Abubakar Bobbo, Khadijat
Ahmad, Umar
Chau, De-Ming
Nordin, Norshariza
Abdullah, Syahril
author_facet Abubakar Bobbo, Khadijat
Ahmad, Umar
Chau, De-Ming
Nordin, Norshariza
Abdullah, Syahril
author_sort Abubakar Bobbo, Khadijat
collection PubMed
description Cystic fibrosis (CF) was earlier thought to be a disease prevalent in the West among Caucasians. However, quite a number of recent studies have uncovered CF cases outside of this region, and reported hundreds of unique and novel variant forms of CFTR. Here, we discuss the evidence of CF in parts of the world earlier considered to be rare; Africa, and Asia. This review also highlighted the CFTR mutation variations and new mutations discovered in these regions. This discovery implies that the CF data from these regions were earlier underestimated. The inadequate awareness of the disease in these regions might have contributed towards the poor diagnostic facilities, under-diagnosis or/and under-reporting, and the lack of CF associated health policies. Overall, these regions have a high rate of infant, childhood and early adulthood mortality due to CF. Therefore, there is a need for a thorough investigation of CF prevalence and to identify unique and novel variant mutations within these regions in order to formulate intervention plans, create awareness, develop mutation specific screening kits and therapies to keep CF mortality at bay.
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spelling pubmed-102585082023-06-13 A comprehensive review of cystic fibrosis in Africa and Asia Abubakar Bobbo, Khadijat Ahmad, Umar Chau, De-Ming Nordin, Norshariza Abdullah, Syahril Saudi J Biol Sci Review Cystic fibrosis (CF) was earlier thought to be a disease prevalent in the West among Caucasians. However, quite a number of recent studies have uncovered CF cases outside of this region, and reported hundreds of unique and novel variant forms of CFTR. Here, we discuss the evidence of CF in parts of the world earlier considered to be rare; Africa, and Asia. This review also highlighted the CFTR mutation variations and new mutations discovered in these regions. This discovery implies that the CF data from these regions were earlier underestimated. The inadequate awareness of the disease in these regions might have contributed towards the poor diagnostic facilities, under-diagnosis or/and under-reporting, and the lack of CF associated health policies. Overall, these regions have a high rate of infant, childhood and early adulthood mortality due to CF. Therefore, there is a need for a thorough investigation of CF prevalence and to identify unique and novel variant mutations within these regions in order to formulate intervention plans, create awareness, develop mutation specific screening kits and therapies to keep CF mortality at bay. Elsevier 2023-07 2023-05-19 /pmc/articles/PMC10258508/ /pubmed/37313453 http://dx.doi.org/10.1016/j.sjbs.2023.103685 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Abubakar Bobbo, Khadijat
Ahmad, Umar
Chau, De-Ming
Nordin, Norshariza
Abdullah, Syahril
A comprehensive review of cystic fibrosis in Africa and Asia
title A comprehensive review of cystic fibrosis in Africa and Asia
title_full A comprehensive review of cystic fibrosis in Africa and Asia
title_fullStr A comprehensive review of cystic fibrosis in Africa and Asia
title_full_unstemmed A comprehensive review of cystic fibrosis in Africa and Asia
title_short A comprehensive review of cystic fibrosis in Africa and Asia
title_sort comprehensive review of cystic fibrosis in africa and asia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258508/
https://www.ncbi.nlm.nih.gov/pubmed/37313453
http://dx.doi.org/10.1016/j.sjbs.2023.103685
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