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Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome
OBJECTIVE: The aim of the present study was to determine whether polycystic ovarian morphology (PCOM) is related to insulin resistance in women with polycystic ovary syndrome (PCOS). METHODS: A total of 147 Korean women aged 18 to 35 years and diagnosed with PCOS were included in this study. Fasting...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Reproductive Medicine
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258515/ https://www.ncbi.nlm.nih.gov/pubmed/37258105 http://dx.doi.org/10.5653/cerm.2023.05855 |
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author | Lee, Jeong Eun Park, Yubin Lee, Jisoo Chun, Sungwook |
author_facet | Lee, Jeong Eun Park, Yubin Lee, Jisoo Chun, Sungwook |
author_sort | Lee, Jeong Eun |
collection | PubMed |
description | OBJECTIVE: The aim of the present study was to determine whether polycystic ovarian morphology (PCOM) is related to insulin resistance in women with polycystic ovary syndrome (PCOS). METHODS: A total of 147 Korean women aged 18 to 35 years and diagnosed with PCOS were included in this study. Fasting blood tests and standard 2-hour 75-g oral glucose tolerance tests were performed for all participants. PCOM-related parameters including total antral follicle count (TFC) and total ovarian volume (TOV) were assessed using transvaginal or transrectal ultrasonography. Correlation analysis was conducted to assess the relationships of TFC and TOV with insulin resistance-related clinical and biochemical parameters using Spearman rank correlation coefficients and linear regression analysis, with partial correlations used to control for the effects of confounding covariates. RESULTS: Fasting insulin levels, low-density lipoprotein levels, and insulin sensitivity assessment indices (ISAIs) were significantly correlated with TFC, but neither postprandial blood glucose levels nor insulin levels were significantly associated with TFC. No insulin resistance-related parameter was significantly correlated with TOV. These results did not change after adjustments for other anthropometric covariates. Fasting insulin and some ISAIs differed significantly between groups categorized by the median TFC value (TFC ≤54 and TFC >54). CONCLUSION: TFC, but not TOV, was found to be related to fasting insulin resistance-related parameters in women with PCOS. |
format | Online Article Text |
id | pubmed-10258515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Society for Reproductive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-102585152023-06-13 Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome Lee, Jeong Eun Park, Yubin Lee, Jisoo Chun, Sungwook Clin Exp Reprod Med Original Article OBJECTIVE: The aim of the present study was to determine whether polycystic ovarian morphology (PCOM) is related to insulin resistance in women with polycystic ovary syndrome (PCOS). METHODS: A total of 147 Korean women aged 18 to 35 years and diagnosed with PCOS were included in this study. Fasting blood tests and standard 2-hour 75-g oral glucose tolerance tests were performed for all participants. PCOM-related parameters including total antral follicle count (TFC) and total ovarian volume (TOV) were assessed using transvaginal or transrectal ultrasonography. Correlation analysis was conducted to assess the relationships of TFC and TOV with insulin resistance-related clinical and biochemical parameters using Spearman rank correlation coefficients and linear regression analysis, with partial correlations used to control for the effects of confounding covariates. RESULTS: Fasting insulin levels, low-density lipoprotein levels, and insulin sensitivity assessment indices (ISAIs) were significantly correlated with TFC, but neither postprandial blood glucose levels nor insulin levels were significantly associated with TFC. No insulin resistance-related parameter was significantly correlated with TOV. These results did not change after adjustments for other anthropometric covariates. Fasting insulin and some ISAIs differed significantly between groups categorized by the median TFC value (TFC ≤54 and TFC >54). CONCLUSION: TFC, but not TOV, was found to be related to fasting insulin resistance-related parameters in women with PCOS. Korean Society for Reproductive Medicine 2023-06 2023-05-11 /pmc/articles/PMC10258515/ /pubmed/37258105 http://dx.doi.org/10.5653/cerm.2023.05855 Text en Copyright © 2023. THE KOREAN SOCIETY FOR REPRODUCTIVE MEDICINE https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Jeong Eun Park, Yubin Lee, Jisoo Chun, Sungwook Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
title | Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
title_full | Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
title_fullStr | Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
title_full_unstemmed | Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
title_short | Association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
title_sort | association between polycystic ovarian morphology and insulin resistance in women with polycystic ovary syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258515/ https://www.ncbi.nlm.nih.gov/pubmed/37258105 http://dx.doi.org/10.5653/cerm.2023.05855 |
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