Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis

BACKGROUND: Recent studies suggest that MEK1/2 inhibitors, including binimetinib, significantly improve malignant melanoma (MM) patient survival. Growing evidence suggests that phytochemicals, especially curcumin, can overcome drug resistance in cancer cells through a variety of mechanisms. OBJECTIV...

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Detalles Bibliográficos
Autores principales: Lee, Yoon Jin, Heo, Jae Young, Kim, Dong Sung, Choi, Yu Sung, Kim, Sooyoung, Nam, Hae Seon, Lee, Sang Han, Cho, Moon Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258547/
https://www.ncbi.nlm.nih.gov/pubmed/37290955
http://dx.doi.org/10.5021/ad.22.200

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