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Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

INTRODUCTION: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). METHODS: MEDLINE, Embase, Sc...

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Autores principales: Yousefifard, Mahmoud, Janzadeh, Atousa, Ali, Kosar Mohamed, Vazirizadeh-Mahabadi, Mohammad Hossein, Sarveazad, Arash, Madani Neishaboori, Arian, Hosseini, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258590/
https://www.ncbi.nlm.nih.gov/pubmed/37313020
http://dx.doi.org/10.32598/bcn.2021.1422.1
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author Yousefifard, Mahmoud
Janzadeh, Atousa
Ali, Kosar Mohamed
Vazirizadeh-Mahabadi, Mohammad Hossein
Sarveazad, Arash
Madani Neishaboori, Arian
Hosseini, Mostafa
author_facet Yousefifard, Mahmoud
Janzadeh, Atousa
Ali, Kosar Mohamed
Vazirizadeh-Mahabadi, Mohammad Hossein
Sarveazad, Arash
Madani Neishaboori, Arian
Hosseini, Mostafa
author_sort Yousefifard, Mahmoud
collection PubMed
description INTRODUCTION: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). METHODS: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). RESULTS: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment. CONCLUSION: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy.
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spelling pubmed-102585902023-06-13 Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis Yousefifard, Mahmoud Janzadeh, Atousa Ali, Kosar Mohamed Vazirizadeh-Mahabadi, Mohammad Hossein Sarveazad, Arash Madani Neishaboori, Arian Hosseini, Mostafa Basic Clin Neurosci Review Article INTRODUCTION: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). METHODS: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). RESULTS: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment. CONCLUSION: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy. Tehran University of Medical Sciences 2022 2022-09-01 /pmc/articles/PMC10258590/ /pubmed/37313020 http://dx.doi.org/10.32598/bcn.2021.1422.1 Text en Copyright© 2022 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Review Article
Yousefifard, Mahmoud
Janzadeh, Atousa
Ali, Kosar Mohamed
Vazirizadeh-Mahabadi, Mohammad Hossein
Sarveazad, Arash
Madani Neishaboori, Arian
Hosseini, Mostafa
Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
title Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
title_full Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
title_fullStr Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
title_full_unstemmed Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
title_short Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
title_sort chondroitinase abc administration in locomotion recovery after spinal cord injury: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258590/
https://www.ncbi.nlm.nih.gov/pubmed/37313020
http://dx.doi.org/10.32598/bcn.2021.1422.1
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