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Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
INTRODUCTION: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). METHODS: MEDLINE, Embase, Sc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258590/ https://www.ncbi.nlm.nih.gov/pubmed/37313020 http://dx.doi.org/10.32598/bcn.2021.1422.1 |
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author | Yousefifard, Mahmoud Janzadeh, Atousa Ali, Kosar Mohamed Vazirizadeh-Mahabadi, Mohammad Hossein Sarveazad, Arash Madani Neishaboori, Arian Hosseini, Mostafa |
author_facet | Yousefifard, Mahmoud Janzadeh, Atousa Ali, Kosar Mohamed Vazirizadeh-Mahabadi, Mohammad Hossein Sarveazad, Arash Madani Neishaboori, Arian Hosseini, Mostafa |
author_sort | Yousefifard, Mahmoud |
collection | PubMed |
description | INTRODUCTION: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). METHODS: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). RESULTS: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment. CONCLUSION: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy. |
format | Online Article Text |
id | pubmed-10258590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-102585902023-06-13 Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis Yousefifard, Mahmoud Janzadeh, Atousa Ali, Kosar Mohamed Vazirizadeh-Mahabadi, Mohammad Hossein Sarveazad, Arash Madani Neishaboori, Arian Hosseini, Mostafa Basic Clin Neurosci Review Article INTRODUCTION: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). METHODS: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). RESULTS: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment. CONCLUSION: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy. Tehran University of Medical Sciences 2022 2022-09-01 /pmc/articles/PMC10258590/ /pubmed/37313020 http://dx.doi.org/10.32598/bcn.2021.1422.1 Text en Copyright© 2022 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Review Article Yousefifard, Mahmoud Janzadeh, Atousa Ali, Kosar Mohamed Vazirizadeh-Mahabadi, Mohammad Hossein Sarveazad, Arash Madani Neishaboori, Arian Hosseini, Mostafa Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
title | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
title_full | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
title_fullStr | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
title_full_unstemmed | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
title_short | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
title_sort | chondroitinase abc administration in locomotion recovery after spinal cord injury: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258590/ https://www.ncbi.nlm.nih.gov/pubmed/37313020 http://dx.doi.org/10.32598/bcn.2021.1422.1 |
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