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Effects of Memantine on the Spontaneous Firing Frequency of Hippocampal CA1 Pyramidal Neurons in Intact and Alzheimer Rat Model: An Electrophysiological Study

INTRODUCTION: Memantine (MEM) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically used for the treatment of Alzheimer disease (AD) in mild to severe conditions. The present study was conducted to investigate the effects of memantine on the spontaneous firing frequency of...

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Detalles Bibliográficos
Autores principales: Zamani, Nastaran, Moazedi, Ahmad Ali, Afarinesh Khaki, Mohamad Reza, Pourmehdi Boroujeni, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258597/
https://www.ncbi.nlm.nih.gov/pubmed/37313029
http://dx.doi.org/10.32598/bcn.2021.1970.1