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Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes
Diabetes is the ninth leading cause of death, directly accounting for 1.5 million deaths annually worldwide. Despite several breakthrough discoveries, little progress has been made in type 2 diabetes outcomes over the past 100 years. Younger age (below 60 years), a diet high in calories and processe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Touch Medical Media
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258620/ https://www.ncbi.nlm.nih.gov/pubmed/37313244 http://dx.doi.org/10.17925/EE.2023.19.1.33 |
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author | Chockalingam, Anand Natarajan, Pandiyan Dorairajan, Smrita Khan, Uzma |
author_facet | Chockalingam, Anand Natarajan, Pandiyan Dorairajan, Smrita Khan, Uzma |
author_sort | Chockalingam, Anand |
collection | PubMed |
description | Diabetes is the ninth leading cause of death, directly accounting for 1.5 million deaths annually worldwide. Despite several breakthrough discoveries, little progress has been made in type 2 diabetes outcomes over the past 100 years. Younger age (below 60 years), a diet high in calories and processed food, and severe obesity (body mass index >35 kg/m(2)) may identify reversible beta cell dysfunction. Much of the clinical presentation pertains to flooding the body’s adaptive limits with overnutrition. Recognizing this as a global societal trend brought about by lifestyle changes, sedentary work, mental stress and unlimited access to calorie-dense foods is crucial. Insulin resistance and genetic abnormalities cannot account for the dramatic increase in diabetes, from only 1% five decades ago to nearly 10% today. Obesity – and not insulin resistance – is at the core of the problem. As well as hyperglycaemia, end-organ damage can also be reversed with diet and weight loss in many affected individuals. We present the evolution of our understanding and compelling reasons to reframe diabetes in the severely obese to what it really is – overweight hyperglycaemia. This may shift societal perception, governmental funding, workplace reformations and individual engagement with healthy lifestyles. The objective of this review is to better understand global trends and the potential to improve outcomes by reframing the diabetes narrative towards remission. This may shift societal perception, governmental funding, workplace reformations and individual engagement with healthy lifestyles. |
format | Online Article Text |
id | pubmed-10258620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Touch Medical Media |
record_format | MEDLINE/PubMed |
spelling | pubmed-102586202023-06-13 Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes Chockalingam, Anand Natarajan, Pandiyan Dorairajan, Smrita Khan, Uzma touchREV Endocrinol Diabetes Diabetes is the ninth leading cause of death, directly accounting for 1.5 million deaths annually worldwide. Despite several breakthrough discoveries, little progress has been made in type 2 diabetes outcomes over the past 100 years. Younger age (below 60 years), a diet high in calories and processed food, and severe obesity (body mass index >35 kg/m(2)) may identify reversible beta cell dysfunction. Much of the clinical presentation pertains to flooding the body’s adaptive limits with overnutrition. Recognizing this as a global societal trend brought about by lifestyle changes, sedentary work, mental stress and unlimited access to calorie-dense foods is crucial. Insulin resistance and genetic abnormalities cannot account for the dramatic increase in diabetes, from only 1% five decades ago to nearly 10% today. Obesity – and not insulin resistance – is at the core of the problem. As well as hyperglycaemia, end-organ damage can also be reversed with diet and weight loss in many affected individuals. We present the evolution of our understanding and compelling reasons to reframe diabetes in the severely obese to what it really is – overweight hyperglycaemia. This may shift societal perception, governmental funding, workplace reformations and individual engagement with healthy lifestyles. The objective of this review is to better understand global trends and the potential to improve outcomes by reframing the diabetes narrative towards remission. This may shift societal perception, governmental funding, workplace reformations and individual engagement with healthy lifestyles. Touch Medical Media 2023-05 2023-03-27 /pmc/articles/PMC10258620/ /pubmed/37313244 http://dx.doi.org/10.17925/EE.2023.19.1.33 Text en © Touch Medical Media 2023 ali:free_to_read www.copyright.com (http://www.copyright.com) Review process: Double-blind peer review. Compliance with ethics: This article involves a review of the literature and did not involve any studies with human or animal subjects performed by any of the authors. Data availability: Data sharing is not applicable to this article as no datasets were generated or analysed during the writing of this article. Authorship: The named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published. https://creativecommons.org/licenses/by/3.0/Access: This article is freely accessible at touchENDOCRINOLOGY.com (http://touchENDOCRINOLOGY.com) . © Touch Medical Media 2023 |
spellingShingle | Diabetes Chockalingam, Anand Natarajan, Pandiyan Dorairajan, Smrita Khan, Uzma Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes |
title | Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes |
title_full | Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes |
title_fullStr | Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes |
title_full_unstemmed | Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes |
title_short | Early Recognition of Overweight Hyperglycaemia May Improve Clinical Outcomes in Type 2 Diabetes |
title_sort | early recognition of overweight hyperglycaemia may improve clinical outcomes in type 2 diabetes |
topic | Diabetes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258620/ https://www.ncbi.nlm.nih.gov/pubmed/37313244 http://dx.doi.org/10.17925/EE.2023.19.1.33 |
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