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mRNA expression of caspase 14 in skin epithelial malignancies
INTRODUCTION: The skin is the largest organ in the human body and it is also a complex organ. Its protective function is properly maintained due to its continuous renewal. Malignancies develop when the balance between proliferation and cell death is dysregulated in skin cells. Skin epithelial cancer...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258700/ https://www.ncbi.nlm.nih.gov/pubmed/37312914 http://dx.doi.org/10.5114/ada.2023.127646 |
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author | Markiewicz, Agnieszka Sigorski, Dawid Markiewicz, Mateusz Placek, Waldemar J. Owczarczyk-Saczonek, Agnieszka Barbara |
author_facet | Markiewicz, Agnieszka Sigorski, Dawid Markiewicz, Mateusz Placek, Waldemar J. Owczarczyk-Saczonek, Agnieszka Barbara |
author_sort | Markiewicz, Agnieszka |
collection | PubMed |
description | INTRODUCTION: The skin is the largest organ in the human body and it is also a complex organ. Its protective function is properly maintained due to its continuous renewal. Malignancies develop when the balance between proliferation and cell death is dysregulated in skin cells. Skin epithelial cancers are the most common neoplasms in humans. Although caspases are proteins which regulate the cell cycle and cell death, caspase 14 is a unique representative of the caspase family which does not participate in apoptosis. The detailed role of caspase 14 in skin epithelial malignancies has not been elucidated. MATERIAL AND METHODS: We performed a prospective study aimed at the analysis of the mRNA expression of caspase 14 in groups of skin epithelial malignancies. We enrolled 56 patients (control group n = 21, study group n = 35). The mRNA expression of caspase 14 was lower in the non-lesional skin of patients with basal cell cancer or squamous cell cancer compared to a combined group of non-lesional samples from actinic keratosis patients and the control group. RESULTS: The prognostic potential of caspase 14 mRNA is suggested when trying to identify patients predisposed to skin cancer. Moreover, the expression level was lower in combined groups of non-lesional skin obtained from patients with basal cell cancer (BCC)/squamous cell cancer (SCC) in comparison with lesional samples obtained from patients with BCC/SCC. CONCLUSIONS: We present primary results of a pilot study and define further goals for research continuation. |
format | Online Article Text |
id | pubmed-10258700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-102587002023-06-13 mRNA expression of caspase 14 in skin epithelial malignancies Markiewicz, Agnieszka Sigorski, Dawid Markiewicz, Mateusz Placek, Waldemar J. Owczarczyk-Saczonek, Agnieszka Barbara Postepy Dermatol Alergol Original Paper INTRODUCTION: The skin is the largest organ in the human body and it is also a complex organ. Its protective function is properly maintained due to its continuous renewal. Malignancies develop when the balance between proliferation and cell death is dysregulated in skin cells. Skin epithelial cancers are the most common neoplasms in humans. Although caspases are proteins which regulate the cell cycle and cell death, caspase 14 is a unique representative of the caspase family which does not participate in apoptosis. The detailed role of caspase 14 in skin epithelial malignancies has not been elucidated. MATERIAL AND METHODS: We performed a prospective study aimed at the analysis of the mRNA expression of caspase 14 in groups of skin epithelial malignancies. We enrolled 56 patients (control group n = 21, study group n = 35). The mRNA expression of caspase 14 was lower in the non-lesional skin of patients with basal cell cancer or squamous cell cancer compared to a combined group of non-lesional samples from actinic keratosis patients and the control group. RESULTS: The prognostic potential of caspase 14 mRNA is suggested when trying to identify patients predisposed to skin cancer. Moreover, the expression level was lower in combined groups of non-lesional skin obtained from patients with basal cell cancer (BCC)/squamous cell cancer (SCC) in comparison with lesional samples obtained from patients with BCC/SCC. CONCLUSIONS: We present primary results of a pilot study and define further goals for research continuation. Termedia Publishing House 2023-05-31 2023-04 /pmc/articles/PMC10258700/ /pubmed/37312914 http://dx.doi.org/10.5114/ada.2023.127646 Text en Copyright: © 2023 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Markiewicz, Agnieszka Sigorski, Dawid Markiewicz, Mateusz Placek, Waldemar J. Owczarczyk-Saczonek, Agnieszka Barbara mRNA expression of caspase 14 in skin epithelial malignancies |
title | mRNA expression of caspase 14 in skin epithelial malignancies |
title_full | mRNA expression of caspase 14 in skin epithelial malignancies |
title_fullStr | mRNA expression of caspase 14 in skin epithelial malignancies |
title_full_unstemmed | mRNA expression of caspase 14 in skin epithelial malignancies |
title_short | mRNA expression of caspase 14 in skin epithelial malignancies |
title_sort | mrna expression of caspase 14 in skin epithelial malignancies |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258700/ https://www.ncbi.nlm.nih.gov/pubmed/37312914 http://dx.doi.org/10.5114/ada.2023.127646 |
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