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Interleukins 20 and 8 – less widely known cytokines in psoriasis

Psoriasis is a common immune-mediated inflammatory dermatosis affecting 2–3% of the northern European population. Although its aetiology is not completely elucidated, it is widely accepted that activated immune cells and keratinocytes stimulate keratinocyte hyperproliferation by production of cytoki...

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Autores principales: Kutwin, Magdalena, Woźniacka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258704/
https://www.ncbi.nlm.nih.gov/pubmed/37312911
http://dx.doi.org/10.5114/ada.2022.119077
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author Kutwin, Magdalena
Woźniacka, Anna
author_facet Kutwin, Magdalena
Woźniacka, Anna
author_sort Kutwin, Magdalena
collection PubMed
description Psoriasis is a common immune-mediated inflammatory dermatosis affecting 2–3% of the northern European population. Although its aetiology is not completely elucidated, it is widely accepted that activated immune cells and keratinocytes stimulate keratinocyte hyperproliferation by production of cytokines; indeed, elevated amounts of pro-inflammatory cytokines have been observed in skin lesions and patient serum. By identifying those playing a central role in the disease pathogenesis, it will be possible to indicate a potential therapeutic target. Drugs targeting tumour necrosis factor α (TNF-α), interleukin (IL)-12/23, IL-17, IL-22 and IL-23 and Janus kinase inhibitors have been found to successfully alleviate resistant skin lesions. However, psoriasis is a complex disease with varied cellular interactions and cytokines, and a complex receptor network. Therefore, this review paper examines the less widely known cytokines IL-20 and IL-8, their therapeutic potential and their role in skin lesion development. Although promising results have been obtained for IL-20 and IL-8 treatment, and their role in the psoriasis skin lesion development is well documented, the role of these two cytokines remains overshadowed by that of the wider systemic cytokine storm.
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spelling pubmed-102587042023-06-13 Interleukins 20 and 8 – less widely known cytokines in psoriasis Kutwin, Magdalena Woźniacka, Anna Postepy Dermatol Alergol Review Paper Psoriasis is a common immune-mediated inflammatory dermatosis affecting 2–3% of the northern European population. Although its aetiology is not completely elucidated, it is widely accepted that activated immune cells and keratinocytes stimulate keratinocyte hyperproliferation by production of cytokines; indeed, elevated amounts of pro-inflammatory cytokines have been observed in skin lesions and patient serum. By identifying those playing a central role in the disease pathogenesis, it will be possible to indicate a potential therapeutic target. Drugs targeting tumour necrosis factor α (TNF-α), interleukin (IL)-12/23, IL-17, IL-22 and IL-23 and Janus kinase inhibitors have been found to successfully alleviate resistant skin lesions. However, psoriasis is a complex disease with varied cellular interactions and cytokines, and a complex receptor network. Therefore, this review paper examines the less widely known cytokines IL-20 and IL-8, their therapeutic potential and their role in skin lesion development. Although promising results have been obtained for IL-20 and IL-8 treatment, and their role in the psoriasis skin lesion development is well documented, the role of these two cytokines remains overshadowed by that of the wider systemic cytokine storm. Termedia Publishing House 2022-08-29 2023-04 /pmc/articles/PMC10258704/ /pubmed/37312911 http://dx.doi.org/10.5114/ada.2022.119077 Text en Copyright: © 2022 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Kutwin, Magdalena
Woźniacka, Anna
Interleukins 20 and 8 – less widely known cytokines in psoriasis
title Interleukins 20 and 8 – less widely known cytokines in psoriasis
title_full Interleukins 20 and 8 – less widely known cytokines in psoriasis
title_fullStr Interleukins 20 and 8 – less widely known cytokines in psoriasis
title_full_unstemmed Interleukins 20 and 8 – less widely known cytokines in psoriasis
title_short Interleukins 20 and 8 – less widely known cytokines in psoriasis
title_sort interleukins 20 and 8 – less widely known cytokines in psoriasis
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258704/
https://www.ncbi.nlm.nih.gov/pubmed/37312911
http://dx.doi.org/10.5114/ada.2022.119077
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