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Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat

Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain fatty acid that is the primary precursor of lipid metabolism and an important intracellular signaling molecule. FASN is an attractive drug target in diabetes, cancer, fatty liver diseases, and viral infections...

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Detalles Bibliográficos
Autores principales:	Hasan, S. M. Naimul, Lou, Jennifer W., Keszei, Alexander F. A., Dai, David L., Mazhab-Jafari, Mohammad T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258763/ https://www.ncbi.nlm.nih.gov/pubmed/37308485 http://dx.doi.org/10.1038/s41467-023-39266-y

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