Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors

[Image: see text] To discover novel carbonic anhydrase (CA, EC 4.2.1.1) inhibitors for cancer treatment, a series of 4-{4-[(hydroxyimino)methyl]piperazin-1-yl}benzenesulfonamides were designed and synthesized using SLC-0111 as the lead molecule. The developed novel compounds 27–34 were investigated...

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Detalles Bibliográficos
Autores principales: Peerzada, Mudasir Nabi, Vullo, Daniela, Paoletti, Niccolò, Bonardi, Alessandro, Gratteri, Paola, Supuran, Claudiu T., Azam, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258898/
https://www.ncbi.nlm.nih.gov/pubmed/37312840
http://dx.doi.org/10.1021/acsmedchemlett.3c00094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258898/
https://www.ncbi.nlm.nih.gov/pubmed/37312840
http://dx.doi.org/10.1021/acsmedchemlett.3c00094

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