Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock

BACKGROUND: Sepsis-induced endothelial dysfunction is proposed to cause angiotensin-converting enzyme (ACE) dysfunction and renin–angiotensin–aldosterone system (RAAS) derangement, exacerbating vasodilatory shock and acute kidney injury (AKI). Few studies test this hypothesis directly, including non...

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Detalles Bibliográficos
Autores principales: Pode-Shakked, Naomi, Ceschia, Giovanni, Rose, James E., Goldstein, Stuart L., Stanski, Natalja L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259008/
https://www.ncbi.nlm.nih.gov/pubmed/37308975
http://dx.doi.org/10.1186/s13054-023-04518-2

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