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Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease

Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limitation for many studies is the ability to sample the...

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Autores principales: Milicic, Lidija, Porter, Tenielle, Vacher, Michael, Laws, Simon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259073/
https://www.ncbi.nlm.nih.gov/pubmed/37313495
http://dx.doi.org/10.3233/ADR-220109
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author Milicic, Lidija
Porter, Tenielle
Vacher, Michael
Laws, Simon M.
author_facet Milicic, Lidija
Porter, Tenielle
Vacher, Michael
Laws, Simon M.
author_sort Milicic, Lidija
collection PubMed
description Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limitation for many studies is the ability to sample the tissue of interest, which is why there is a need for a proxy tissue such as blood, that is reflective of the methylation state of the target tissue. In the last decade, DNA methylation has been utilized in the design of epigenetic clocks, which aim to predict an individual’s biological age based on an algorithmically defined set of CpGs. A number of studies have found associations between disease and/or disease risk with increased biological age, adding weight to the theory of increased biological age being linked with disease processes. Hence, this review takes a closer look at the utility of DNA methylation as a biomarker in aging and disease, with a particular focus on Alzheimer’s disease.
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spelling pubmed-102590732023-06-13 Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease Milicic, Lidija Porter, Tenielle Vacher, Michael Laws, Simon M. J Alzheimers Dis Rep Review Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limitation for many studies is the ability to sample the tissue of interest, which is why there is a need for a proxy tissue such as blood, that is reflective of the methylation state of the target tissue. In the last decade, DNA methylation has been utilized in the design of epigenetic clocks, which aim to predict an individual’s biological age based on an algorithmically defined set of CpGs. A number of studies have found associations between disease and/or disease risk with increased biological age, adding weight to the theory of increased biological age being linked with disease processes. Hence, this review takes a closer look at the utility of DNA methylation as a biomarker in aging and disease, with a particular focus on Alzheimer’s disease. IOS Press 2023-05-31 /pmc/articles/PMC10259073/ /pubmed/37313495 http://dx.doi.org/10.3233/ADR-220109 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Milicic, Lidija
Porter, Tenielle
Vacher, Michael
Laws, Simon M.
Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
title Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
title_full Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
title_fullStr Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
title_full_unstemmed Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
title_short Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
title_sort utility of dna methylation as a biomarker in aging and alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259073/
https://www.ncbi.nlm.nih.gov/pubmed/37313495
http://dx.doi.org/10.3233/ADR-220109
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