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A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong

BACKGROUND: Understanding factors associated with SARS-CoV-2 exposure risk in the hospital setting may help improve infection control measures for prevention. AIM: To monitor SARS-CoV-2 exposure risk among healthcare workers and to identify risk factors associated with SARS-CoV-2 detection. METHODS:...

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Autores principales: Yung, Louise, Leung, Ling Yan, Lee, Kwok Hung, Morrell, Steven, Fong, Min Whui, Yan Fung, Nikki Ho, Cheng, Kit Ling, Kaewpreedee, Prathanporn, Li, Yuguo, Cowling, Benjamin J., Lau, Eric HY., Hui, David SC., Graham, Colin A., Yen, Hui-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259104/
https://www.ncbi.nlm.nih.gov/pubmed/37315806
http://dx.doi.org/10.1016/j.jhin.2023.05.020
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author Yung, Louise
Leung, Ling Yan
Lee, Kwok Hung
Morrell, Steven
Fong, Min Whui
Yan Fung, Nikki Ho
Cheng, Kit Ling
Kaewpreedee, Prathanporn
Li, Yuguo
Cowling, Benjamin J.
Lau, Eric HY.
Hui, David SC.
Graham, Colin A.
Yen, Hui-Ling
author_facet Yung, Louise
Leung, Ling Yan
Lee, Kwok Hung
Morrell, Steven
Fong, Min Whui
Yan Fung, Nikki Ho
Cheng, Kit Ling
Kaewpreedee, Prathanporn
Li, Yuguo
Cowling, Benjamin J.
Lau, Eric HY.
Hui, David SC.
Graham, Colin A.
Yen, Hui-Ling
author_sort Yung, Louise
collection PubMed
description BACKGROUND: Understanding factors associated with SARS-CoV-2 exposure risk in the hospital setting may help improve infection control measures for prevention. AIM: To monitor SARS-CoV-2 exposure risk among healthcare workers and to identify risk factors associated with SARS-CoV-2 detection. METHODS: Surface and air samples were collected longitudinally over 14 months spanning 2020-2022 at the Emergency Department (ED) of a teaching hospital in Hong Kong. SARS-CoV-2 viral RNA was detected by real-time reverse-transcription polymerase chain reaction. Ecological factors associated with SARS-CoV-2 detection were analysed by logistic regression. A sero-epidemiological study was conducted in January to April 2021 to monitor SARS-CoV-2 seroprevalence. A questionnaire was used to collect information on job nature and use of personal protective equipment (PPE) of the participants. FINDINGS: SARS-CoV-2 RNA was detected at low frequencies from surfaces (0.7%, n=2562) and air samples (1.6%, n=128). Crowding was identified as the main risk factor, as weekly ED attendance (OR=1.002, p=0.04) and sampling after peak-hours of ED attendance (OR=5.216, p=0.03) were associated with the detection of SARS-CoV-2 viral RNA from surfaces. The low exposure risk was corroborated by the zero seropositive rate among 281 participants by April 2021. CONCLUSION: Crowding may introduce SARS-CoV-2 into ED through increased attendances. Multiple factors may have contributed to the low contamination of SARS-CoV-2 at the ED, including hospital infection control measures for screening ED attendees, high PPE compliance among healthcare workers, and various public health and social measures implemented to reduce community transmission in Hong Kong where a dynamic zero COVID-19 policy was adopted.
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spelling pubmed-102591042023-06-12 A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong Yung, Louise Leung, Ling Yan Lee, Kwok Hung Morrell, Steven Fong, Min Whui Yan Fung, Nikki Ho Cheng, Kit Ling Kaewpreedee, Prathanporn Li, Yuguo Cowling, Benjamin J. Lau, Eric HY. Hui, David SC. Graham, Colin A. Yen, Hui-Ling J Hosp Infect Article BACKGROUND: Understanding factors associated with SARS-CoV-2 exposure risk in the hospital setting may help improve infection control measures for prevention. AIM: To monitor SARS-CoV-2 exposure risk among healthcare workers and to identify risk factors associated with SARS-CoV-2 detection. METHODS: Surface and air samples were collected longitudinally over 14 months spanning 2020-2022 at the Emergency Department (ED) of a teaching hospital in Hong Kong. SARS-CoV-2 viral RNA was detected by real-time reverse-transcription polymerase chain reaction. Ecological factors associated with SARS-CoV-2 detection were analysed by logistic regression. A sero-epidemiological study was conducted in January to April 2021 to monitor SARS-CoV-2 seroprevalence. A questionnaire was used to collect information on job nature and use of personal protective equipment (PPE) of the participants. FINDINGS: SARS-CoV-2 RNA was detected at low frequencies from surfaces (0.7%, n=2562) and air samples (1.6%, n=128). Crowding was identified as the main risk factor, as weekly ED attendance (OR=1.002, p=0.04) and sampling after peak-hours of ED attendance (OR=5.216, p=0.03) were associated with the detection of SARS-CoV-2 viral RNA from surfaces. The low exposure risk was corroborated by the zero seropositive rate among 281 participants by April 2021. CONCLUSION: Crowding may introduce SARS-CoV-2 into ED through increased attendances. Multiple factors may have contributed to the low contamination of SARS-CoV-2 at the ED, including hospital infection control measures for screening ED attendees, high PPE compliance among healthcare workers, and various public health and social measures implemented to reduce community transmission in Hong Kong where a dynamic zero COVID-19 policy was adopted. The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society. 2023-06-12 /pmc/articles/PMC10259104/ /pubmed/37315806 http://dx.doi.org/10.1016/j.jhin.2023.05.020 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yung, Louise
Leung, Ling Yan
Lee, Kwok Hung
Morrell, Steven
Fong, Min Whui
Yan Fung, Nikki Ho
Cheng, Kit Ling
Kaewpreedee, Prathanporn
Li, Yuguo
Cowling, Benjamin J.
Lau, Eric HY.
Hui, David SC.
Graham, Colin A.
Yen, Hui-Ling
A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong
title A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong
title_full A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong
title_fullStr A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong
title_full_unstemmed A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong
title_short A longitudinal environmental surveillance study for SARS-CoV-2 from the emergency department of a teaching hospital in Hong Kong
title_sort longitudinal environmental surveillance study for sars-cov-2 from the emergency department of a teaching hospital in hong kong
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259104/
https://www.ncbi.nlm.nih.gov/pubmed/37315806
http://dx.doi.org/10.1016/j.jhin.2023.05.020
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