Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension

INTRODUCTION: Pulmonary arterial hypertension (PAH) is characterised by loss of microvessels. The Wnt pathways control pulmonary angiogenesis but their role in PAH is incompletely understood. We hypothesised that Wnt activation in pulmonary microvascular endothelial cells (PMVECs) is required for pu...

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Detalles Bibliográficos
Autores principales: Chakraborty, Ananya, Nathan, Abinaya, Orcholski, Mark, Agarwal, Stuti, Shamskhou, Elya A., Auer, Natasha, Mitra, Ankita, Guardado, Eleana Stephanie, Swaminathan, Gowri, Condon, David F., Yu, Joyce, McCarra, Matthew, Juul, Nicholas H., Mallory, Alden, Guzman-Hernandez, Roberto A., Yuan, Ke, Rojas, Vanesa, Crossno, Joseph T., Yung, Lai-Ming, Yu, Paul B., Spencer, Thomas, Winn, Robert A., Frump, Andrea, Karoor, Vijaya, Lahm, Tim, Hedlin, Haley, Fineman, Jeffrey R., Lafyatis, Robert, Knutsen, Carsten N.F., Alvira, Cristina M., Cornfield, David N., de Jesus Perez, Vinicio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259331/
https://www.ncbi.nlm.nih.gov/pubmed/37024132
http://dx.doi.org/10.1183/13993003.01625-2022

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