Comparing chronic obstructive pulmonary disease and depressive disorder in terms of inflammation-related biomarkers

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is characterized by the presence of depressive symptoms. METHODS: Cytokine and deiodinase iodothyronines (DIOs) levels were evaluated in COPD patients and patients diagnosed with depressive disorder and control individuals. using enzyme-linked immunosorbent assays. RESULTS: Interleukin 1β (IL-1β), and tumor necrosis factor-α (TNF-α) levels were higher in COPD and depression patients than in control individuals. DIO2 were significantly lower in COPD and recurrent depressive disorder (rDD) patients than in controls. CONCLUSIONS: Changes in the levels of IL-1β, TNF-α and DIO2 in COPD patients may explain the presence of depression in COPD patients.