The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats

INTRODUCTION: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). METHODS: Twenty male adult Wistar rats were randomly distributed...

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Detalles Bibliográficos
Autores principales: Ali, Hirowati, Tofrizal, Tofrizal, Tjong, Djong Hon, Yanis, Amel, Yarni, Sisca Dwi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259384/
https://www.ncbi.nlm.nih.gov/pubmed/37313182
http://dx.doi.org/10.5114/aoms/163353
Descripción
Sumario:INTRODUCTION: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). METHODS: Twenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl(3) group was given 300 mg/kg body weight (BW) of AlCl(3) intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed. RESULTS: MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group. CONCLUSIONS: MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.

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