The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats

INTRODUCTION: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). METHODS: Twenty male adult Wistar rats were randomly distributed...

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Autores principales: Ali, Hirowati, Tofrizal, Tofrizal, Tjong, Djong Hon, Yanis, Amel, Yarni, Sisca Dwi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259384/
https://www.ncbi.nlm.nih.gov/pubmed/37313182
http://dx.doi.org/10.5114/aoms/163353
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author Ali, Hirowati
Tofrizal, Tofrizal
Tjong, Djong Hon
Yanis, Amel
Yarni, Sisca Dwi
author_facet Ali, Hirowati
Tofrizal, Tofrizal
Tjong, Djong Hon
Yanis, Amel
Yarni, Sisca Dwi
author_sort Ali, Hirowati
collection PubMed
description INTRODUCTION: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). METHODS: Twenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl(3) group was given 300 mg/kg body weight (BW) of AlCl(3) intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed. RESULTS: MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group. CONCLUSIONS: MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.
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spelling pubmed-102593842023-06-13 The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats Ali, Hirowati Tofrizal, Tofrizal Tjong, Djong Hon Yanis, Amel Yarni, Sisca Dwi Arch Med Sci Research Letter INTRODUCTION: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). METHODS: Twenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl(3) group was given 300 mg/kg body weight (BW) of AlCl(3) intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed. RESULTS: MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group. CONCLUSIONS: MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model. Termedia Publishing House 2023-05-24 /pmc/articles/PMC10259384/ /pubmed/37313182 http://dx.doi.org/10.5114/aoms/163353 Text en Copyright: © 2023 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Ali, Hirowati
Tofrizal, Tofrizal
Tjong, Djong Hon
Yanis, Amel
Yarni, Sisca Dwi
The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
title The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
title_full The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
title_fullStr The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
title_full_unstemmed The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
title_short The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
title_sort ryr3 gene is involved in wharton’s jelly derived mesenchymal stem cell treatment of alzheimer’s disease in rats
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259384/
https://www.ncbi.nlm.nih.gov/pubmed/37313182
http://dx.doi.org/10.5114/aoms/163353
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