Iron deficiency in sepsis patients based on reticulocyte hemoglobin and hepcidin concentration: a prospective cohort study

INTRODUCTION: Iron tests are deranged in sepsis; therefore new biomarkers should be used for diagnosis of iron deficiency (ID)/ID anemia (IDA). METHODS: Diagnosis of ID/IDA was based on reticulocyte (Ret) hemoglobin (Hb) equivalent (Ret-He) and Hb concentration, with hepcidin (Hep) determined retros...

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Detalles Bibliográficos
Autores principales: Czempik, Piotr F., Wiórek, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259408/
https://www.ncbi.nlm.nih.gov/pubmed/37313179
http://dx.doi.org/10.5114/aoms/161802
Descripción
Sumario:INTRODUCTION: Iron tests are deranged in sepsis; therefore new biomarkers should be used for diagnosis of iron deficiency (ID)/ID anemia (IDA). METHODS: Diagnosis of ID/IDA was based on reticulocyte (Ret) hemoglobin (Hb) equivalent (Ret-He) and Hb concentration, with hepcidin (Hep) determined retrospectively. RESULTS: The prevalence of ID and IDA was 7% and 47%, respectively. The AUROCs for Rets number and Hep in prediction of ID/IDA were 0.69 and 0.62, respectively. CONCLUSIONS: Approximately half of sepsis patients are iron-deficient. Number of Rets may be a predictor of ID/IDA when Ret-He is not available. Hepcidin is a poor IDA predictor.

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