A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus can persist and replicate within host cells, evading immune responses, and causing host cell death. Classical methods for assessing S. aureus cytotoxicity are limited by t...

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Detalles Bibliográficos
Autores principales: Hachani, Abderrahman, Giulieri, Stefano G, Guérillot, Romain, Walsh, Calum J, Herisse, Marion, Soe, Ye Mon, Baines, Sarah L, Thomas, David R, Cheung, Shane Doris, Hayes, Ashleigh S, Cho, Ellie, Newton, Hayley J, Pidot, Sacha, Massey, Ruth C, Howden, Benjamin P, Stinear, Timothy P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259494/
https://www.ncbi.nlm.nih.gov/pubmed/37289634
http://dx.doi.org/10.7554/eLife.84778

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