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Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis

BACKGROUND AND AIMS: The annual incidence of early‐onset colorectal cancer (EOCRC) is increasing at an alarming rate. The prognosis of EOCRC remains controversial, and whether the early onset is a risk factor for colorectal cancer remains unclear. METHODS: We searched four electronic bibliographic d...

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Autores principales: Jin, Taojun, Li, Xinxing, Ji, Jianmei, Li, Jue, Yin, Xiaomao, Xu, Kai, Wang, Wenqiang, Zhang, Wei, Xu, Xiaowen, Hu, Zhiqian, Gong, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259524/
https://www.ncbi.nlm.nih.gov/pubmed/37313533
http://dx.doi.org/10.1002/hsr2.1307
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author Jin, Taojun
Li, Xinxing
Ji, Jianmei
Li, Jue
Yin, Xiaomao
Xu, Kai
Wang, Wenqiang
Zhang, Wei
Xu, Xiaowen
Hu, Zhiqian
Gong, Biao
author_facet Jin, Taojun
Li, Xinxing
Ji, Jianmei
Li, Jue
Yin, Xiaomao
Xu, Kai
Wang, Wenqiang
Zhang, Wei
Xu, Xiaowen
Hu, Zhiqian
Gong, Biao
author_sort Jin, Taojun
collection PubMed
description BACKGROUND AND AIMS: The annual incidence of early‐onset colorectal cancer (EOCRC) is increasing at an alarming rate. The prognosis of EOCRC remains controversial, and whether the early onset is a risk factor for colorectal cancer remains unclear. METHODS: We searched four electronic bibliographic databases from database inception to April 25, 2022 for studies that included both early‐ and later‐onset patients and performed a prognostic analysis. Random‐effects models were used to summarize the prognostic information extracted by the investigators, including overall survival (OS), cancer‐special survival (CSS), and disease‐free survival (DFS). Network meta‐analysis (NMA) was used to compare patients' long‐term prognoses in different age subgroups. RESULTS: After 694 reports were screened, 13 studies were included in the final analysis, with a total of 448,781 CRC cases. In the meta‐analysis of the 5‐year OS, EOCRC had a better prognosis compared to LOCRC (hazard ratio [HR] 0.87, 95% confidence interval [CI], 0.74–0.99; relative risk [RR] 0.83, 95% CI, 0.78–0.89). No difference in prognosis was found between the two groups in terms of 5‐year CSS (RR 0.99, 95% CI, 0.93–1.05), 5‐year DFS (RR 0.90, 95% CI, 0.74–1.09), and short‐term OS. In the NMA, patients aged <30 years had the worst outcome (surface under the cumulative ranking curve [SUCRA], 15.8%) in 5‐year OS; consistent results were observed in the analysis of 5‐year CSS (<30 years, SUCRA 4.5%), but the difference was not statistically significant. CONCLUSION: Although patients with early‐onset CRC had better OS than those with later‐onset CRC, there was no difference in the CSS. Meanwhile, the trend for survival was worse in younger patients, especially in those ages 18–29 years. Thus, more attention should be paid to early diagnosis and treatment of EOCRC. SYSTEMATIC REVIEW AND META‐ANALYSIS REGISTRATION: The systematic review and Meta‐analysis protocol was registered with PROSPERO (registration number CRD42022334697).
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spelling pubmed-102595242023-06-13 Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis Jin, Taojun Li, Xinxing Ji, Jianmei Li, Jue Yin, Xiaomao Xu, Kai Wang, Wenqiang Zhang, Wei Xu, Xiaowen Hu, Zhiqian Gong, Biao Health Sci Rep Original Research BACKGROUND AND AIMS: The annual incidence of early‐onset colorectal cancer (EOCRC) is increasing at an alarming rate. The prognosis of EOCRC remains controversial, and whether the early onset is a risk factor for colorectal cancer remains unclear. METHODS: We searched four electronic bibliographic databases from database inception to April 25, 2022 for studies that included both early‐ and later‐onset patients and performed a prognostic analysis. Random‐effects models were used to summarize the prognostic information extracted by the investigators, including overall survival (OS), cancer‐special survival (CSS), and disease‐free survival (DFS). Network meta‐analysis (NMA) was used to compare patients' long‐term prognoses in different age subgroups. RESULTS: After 694 reports were screened, 13 studies were included in the final analysis, with a total of 448,781 CRC cases. In the meta‐analysis of the 5‐year OS, EOCRC had a better prognosis compared to LOCRC (hazard ratio [HR] 0.87, 95% confidence interval [CI], 0.74–0.99; relative risk [RR] 0.83, 95% CI, 0.78–0.89). No difference in prognosis was found between the two groups in terms of 5‐year CSS (RR 0.99, 95% CI, 0.93–1.05), 5‐year DFS (RR 0.90, 95% CI, 0.74–1.09), and short‐term OS. In the NMA, patients aged <30 years had the worst outcome (surface under the cumulative ranking curve [SUCRA], 15.8%) in 5‐year OS; consistent results were observed in the analysis of 5‐year CSS (<30 years, SUCRA 4.5%), but the difference was not statistically significant. CONCLUSION: Although patients with early‐onset CRC had better OS than those with later‐onset CRC, there was no difference in the CSS. Meanwhile, the trend for survival was worse in younger patients, especially in those ages 18–29 years. Thus, more attention should be paid to early diagnosis and treatment of EOCRC. SYSTEMATIC REVIEW AND META‐ANALYSIS REGISTRATION: The systematic review and Meta‐analysis protocol was registered with PROSPERO (registration number CRD42022334697). John Wiley and Sons Inc. 2023-06-12 /pmc/articles/PMC10259524/ /pubmed/37313533 http://dx.doi.org/10.1002/hsr2.1307 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Jin, Taojun
Li, Xinxing
Ji, Jianmei
Li, Jue
Yin, Xiaomao
Xu, Kai
Wang, Wenqiang
Zhang, Wei
Xu, Xiaowen
Hu, Zhiqian
Gong, Biao
Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
title Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
title_full Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
title_fullStr Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
title_full_unstemmed Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
title_short Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
title_sort comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: a systematic review and meta‐analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259524/
https://www.ncbi.nlm.nih.gov/pubmed/37313533
http://dx.doi.org/10.1002/hsr2.1307
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