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Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study

There is a dearth of information on the patterns of electrolyte derangements among perioperative women with obstructed labour. We measured the levels and patterns of electrolyte derangements among women with obstructed labour in eastern Uganda. This was a secondary analysis of data for 389 patients...

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Autores principales: Nantale, Ritah, Mukunya, David, Mugabe, Kenneth, N. Wandabwa, Julius, Obbo, John Stephen, W. Musaba, Milton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259772/
https://www.ncbi.nlm.nih.gov/pubmed/37307269
http://dx.doi.org/10.1371/journal.pgph.0002012
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author Nantale, Ritah
Mukunya, David
Mugabe, Kenneth
N. Wandabwa, Julius
Obbo, John Stephen
W. Musaba, Milton
author_facet Nantale, Ritah
Mukunya, David
Mugabe, Kenneth
N. Wandabwa, Julius
Obbo, John Stephen
W. Musaba, Milton
author_sort Nantale, Ritah
collection PubMed
description There is a dearth of information on the patterns of electrolyte derangements among perioperative women with obstructed labour. We measured the levels and patterns of electrolyte derangements among women with obstructed labour in eastern Uganda. This was a secondary analysis of data for 389 patients with obstructed labour, diagnosed by either an obstetrician or medical officer on duty between July 2018 and June 2019. Five milliliters of venous blood was drawn from the antecubital fossa under an aseptic procedure for electrolytes and complete blood analyses. The primary outcome was the prevalence of electrolyte derangements, defined as values outside the normal ranges: Potassium 3.3–5.1 mmol/L, Sodium 130–148 mmol/L, Chloride 97–109 mmol/L, Magnesium 0.55–1.10 mmol/L, Calcium (Total) 2.05–2.42 mmol/L, and Bicarbonate 20–24 mmol/L. The most prevalent electrolyte derangement was hypobicarbonatemia [85.8% (334/389)], followed by hypocalcaemia [29.1% (113/389)], then hyponatremia [18% (70/389)]. Hyperchloraemia [4.1% (16/389)], hyperbicarbonatemia [3.1% (12/389)], hypercalcaemia [2.8% (11/389)] and hypermagnesemia [2.8% (11/389)] were seen in a minority of the study participants. A total of 209/389 (53.7%) of the participants had multiple electrolyte derangements. Women who used herbal medicines had 1.6 times the odds of having multiple electrolyte derangements as those who did not use herbal medicines [Adjusted Odds Ratio (AOR): 1.6; 95% Confidence Interval (CI): (1.0–2.5)]. Having multiple electrolyte derangements was associated with perinatal death although this estimate was not precise [AOR 2.1; 95% CI: (0.9–4.7)]. Women with obstructed labour in the perioperative period have multiple electrolyte derangements. Use of herbal medicines in labour was associated with having multiple electrolyte derangements. We recommend routine assessment of electrolytes prior to surgery in patients with obstructed labour.
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spelling pubmed-102597722023-06-13 Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study Nantale, Ritah Mukunya, David Mugabe, Kenneth N. Wandabwa, Julius Obbo, John Stephen W. Musaba, Milton PLOS Glob Public Health Research Article There is a dearth of information on the patterns of electrolyte derangements among perioperative women with obstructed labour. We measured the levels and patterns of electrolyte derangements among women with obstructed labour in eastern Uganda. This was a secondary analysis of data for 389 patients with obstructed labour, diagnosed by either an obstetrician or medical officer on duty between July 2018 and June 2019. Five milliliters of venous blood was drawn from the antecubital fossa under an aseptic procedure for electrolytes and complete blood analyses. The primary outcome was the prevalence of electrolyte derangements, defined as values outside the normal ranges: Potassium 3.3–5.1 mmol/L, Sodium 130–148 mmol/L, Chloride 97–109 mmol/L, Magnesium 0.55–1.10 mmol/L, Calcium (Total) 2.05–2.42 mmol/L, and Bicarbonate 20–24 mmol/L. The most prevalent electrolyte derangement was hypobicarbonatemia [85.8% (334/389)], followed by hypocalcaemia [29.1% (113/389)], then hyponatremia [18% (70/389)]. Hyperchloraemia [4.1% (16/389)], hyperbicarbonatemia [3.1% (12/389)], hypercalcaemia [2.8% (11/389)] and hypermagnesemia [2.8% (11/389)] were seen in a minority of the study participants. A total of 209/389 (53.7%) of the participants had multiple electrolyte derangements. Women who used herbal medicines had 1.6 times the odds of having multiple electrolyte derangements as those who did not use herbal medicines [Adjusted Odds Ratio (AOR): 1.6; 95% Confidence Interval (CI): (1.0–2.5)]. Having multiple electrolyte derangements was associated with perinatal death although this estimate was not precise [AOR 2.1; 95% CI: (0.9–4.7)]. Women with obstructed labour in the perioperative period have multiple electrolyte derangements. Use of herbal medicines in labour was associated with having multiple electrolyte derangements. We recommend routine assessment of electrolytes prior to surgery in patients with obstructed labour. Public Library of Science 2023-06-12 /pmc/articles/PMC10259772/ /pubmed/37307269 http://dx.doi.org/10.1371/journal.pgph.0002012 Text en © 2023 Nantale et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nantale, Ritah
Mukunya, David
Mugabe, Kenneth
N. Wandabwa, Julius
Obbo, John Stephen
W. Musaba, Milton
Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study
title Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study
title_full Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study
title_fullStr Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study
title_full_unstemmed Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study
title_short Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study
title_sort multiple electrolyte derangements among perioperative women with obstructed labour in eastern uganda: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259772/
https://www.ncbi.nlm.nih.gov/pubmed/37307269
http://dx.doi.org/10.1371/journal.pgph.0002012
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