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IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE

Current response assessment in pediatric brain tumors (PBTs), as recommended by the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group, relies on 2D measurements of changes in tumor size. However, there is growing evidence of underestimation of tumor size in PBTs using 2D compared...

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Autores principales: Kazerooni, Anahita Fathi, Khalili, Nastaran, Haldar, Debanjan, Viswanathan, Karthik, Familiar, Ariana, Bagheri, Sina, Anderson, Hannah, Arif, Sherjeel, Madhogarhia, Rachel, Kim, Meen Chul, Mahtabfar, Aria, Storm, Phillip B, Resnick, Adam, Ware, Jeffrey B, Davatzikos, Christos, Vossough, Arastoo, Nabavizadeh, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259909/
http://dx.doi.org/10.1093/neuonc/noad073.182
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author Kazerooni, Anahita Fathi
Khalili, Nastaran
Haldar, Debanjan
Viswanathan, Karthik
Familiar, Ariana
Bagheri, Sina
Anderson, Hannah
Arif, Sherjeel
Madhogarhia, Rachel
Kim, Meen Chul
Mahtabfar, Aria
Storm, Phillip B
Resnick, Adam
Ware, Jeffrey B
Davatzikos, Christos
Vossough, Arastoo
Nabavizadeh, Ali
author_facet Kazerooni, Anahita Fathi
Khalili, Nastaran
Haldar, Debanjan
Viswanathan, Karthik
Familiar, Ariana
Bagheri, Sina
Anderson, Hannah
Arif, Sherjeel
Madhogarhia, Rachel
Kim, Meen Chul
Mahtabfar, Aria
Storm, Phillip B
Resnick, Adam
Ware, Jeffrey B
Davatzikos, Christos
Vossough, Arastoo
Nabavizadeh, Ali
author_sort Kazerooni, Anahita Fathi
collection PubMed
description Current response assessment in pediatric brain tumors (PBTs), as recommended by the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group, relies on 2D measurements of changes in tumor size. However, there is growing evidence of underestimation of tumor size in PBTs using 2D compared to volumetric (3D) measurement approach. Accordingly, automated methods that reduce manual burden and intra- and inter-rater variability in segmenting tumor subregions and volumetric evaluations are warranted to facilitate tumor response assessment of PBTs. We have developed a fully automatic deep learning (DL) model using the nnUNet architecture on a large cohort of multi-institutional and multi-histology PBTs. The model was trained on widely available standard multiparametric MRI sequences (T1-pre, T1-post, T2, T2-FLAIR) for segmentation of the whole tumor and RAPNO-recommended subregions, including enhancing tumor (ET), non-enhancing tumor (NET), cystic components (CC), and peritumoral edema (ED). As a prerequisite step for accurate tumor segmentation, we also generated another DL model based on DeepMedic for brain extraction from mpMRIs. The models were trained on an institutional cohort of 151 subjects and independently tested on 64 subjects from the internal and 29 patients from external institutions. The trained models showed excellent performance with median Dice scores of 0.98±0.02/0.97±0.02 for brain tissue segmentation, 0.92±0.08/0.90±0.17 for whole tumor segmentation, 0.76±0.31/0.87±0.29 for ET subregion, and 0.82±0.15/0.80±0.28 for segmentation of non-enhancing components (combination of NET, CC, and ED) in internal/external test sets, respectively. The automated segmentation demonstrated strong agreement with expert segmentations in volumetric measurement of tumor components, with Pearson’s correlation coefficients of 0.97, 0.97, 0.99, and 0.79 (p<0.0001) for ET, NET, CC, and ED regions, respectively. Our proposed multi-institutional and multi-histology automated segmentation method has the potential to aid clinical neuro-oncology practice by providing reliable and reproducible volumetric measurements for treatment response assessment.
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spelling pubmed-102599092023-06-13 IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE Kazerooni, Anahita Fathi Khalili, Nastaran Haldar, Debanjan Viswanathan, Karthik Familiar, Ariana Bagheri, Sina Anderson, Hannah Arif, Sherjeel Madhogarhia, Rachel Kim, Meen Chul Mahtabfar, Aria Storm, Phillip B Resnick, Adam Ware, Jeffrey B Davatzikos, Christos Vossough, Arastoo Nabavizadeh, Ali Neuro Oncol Final Category: Imaging - IMG Current response assessment in pediatric brain tumors (PBTs), as recommended by the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group, relies on 2D measurements of changes in tumor size. However, there is growing evidence of underestimation of tumor size in PBTs using 2D compared to volumetric (3D) measurement approach. Accordingly, automated methods that reduce manual burden and intra- and inter-rater variability in segmenting tumor subregions and volumetric evaluations are warranted to facilitate tumor response assessment of PBTs. We have developed a fully automatic deep learning (DL) model using the nnUNet architecture on a large cohort of multi-institutional and multi-histology PBTs. The model was trained on widely available standard multiparametric MRI sequences (T1-pre, T1-post, T2, T2-FLAIR) for segmentation of the whole tumor and RAPNO-recommended subregions, including enhancing tumor (ET), non-enhancing tumor (NET), cystic components (CC), and peritumoral edema (ED). As a prerequisite step for accurate tumor segmentation, we also generated another DL model based on DeepMedic for brain extraction from mpMRIs. The models were trained on an institutional cohort of 151 subjects and independently tested on 64 subjects from the internal and 29 patients from external institutions. The trained models showed excellent performance with median Dice scores of 0.98±0.02/0.97±0.02 for brain tissue segmentation, 0.92±0.08/0.90±0.17 for whole tumor segmentation, 0.76±0.31/0.87±0.29 for ET subregion, and 0.82±0.15/0.80±0.28 for segmentation of non-enhancing components (combination of NET, CC, and ED) in internal/external test sets, respectively. The automated segmentation demonstrated strong agreement with expert segmentations in volumetric measurement of tumor components, with Pearson’s correlation coefficients of 0.97, 0.97, 0.99, and 0.79 (p<0.0001) for ET, NET, CC, and ED regions, respectively. Our proposed multi-institutional and multi-histology automated segmentation method has the potential to aid clinical neuro-oncology practice by providing reliable and reproducible volumetric measurements for treatment response assessment. Oxford University Press 2023-06-12 /pmc/articles/PMC10259909/ http://dx.doi.org/10.1093/neuonc/noad073.182 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Final Category: Imaging - IMG
Kazerooni, Anahita Fathi
Khalili, Nastaran
Haldar, Debanjan
Viswanathan, Karthik
Familiar, Ariana
Bagheri, Sina
Anderson, Hannah
Arif, Sherjeel
Madhogarhia, Rachel
Kim, Meen Chul
Mahtabfar, Aria
Storm, Phillip B
Resnick, Adam
Ware, Jeffrey B
Davatzikos, Christos
Vossough, Arastoo
Nabavizadeh, Ali
IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE
title IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE
title_full IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE
title_fullStr IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE
title_full_unstemmed IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE
title_short IMG-05. A MULTI-INSTITUTIONAL AND MULTI-HISTOLOGY PEDIATRIC-SPECIFIC BRAIN TUMOR SUBREGION SEGMENTATION TOOL: FACILITATING RAPNO-BASED ASSESSMENT OF TREATMENT RESPONSE
title_sort img-05. a multi-institutional and multi-histology pediatric-specific brain tumor subregion segmentation tool: facilitating rapno-based assessment of treatment response
topic Final Category: Imaging - IMG
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259909/
http://dx.doi.org/10.1093/neuonc/noad073.182
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